N/A
N=59
Cognitive Training in the Treatment of AUD
Alcohol Use Disorder Cognitive Decline
Bottom Line
View on ClinicalTrials.gov: NCT02664038 ↗Enrolled (actual)
59
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcome: Primary: Days of Heavy Alcohol Use Assessed by Weekly Time Line Follow-back and Breathalyzer — 5.49; 3.0 Days — p=<.05
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Cognitive Remediation Training (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Sep 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Days of Heavy Alcohol Use Assessed by Weekly Time Line Follow-back and Breathalyzer |
1.67; 1.51 | <.05 sig |
| SECONDARY Days of Heavy Alcohol Use Assessed by Weekly Time Line Follow-back and Breathalyzer |
1.67; 1.51 | <.05 sig |
| SECONDARY Penn Alcohol Craving Scale |
3.94; 4.59 | .77 |
| SECONDARY Neurocognitive Composite Score (Average of T-scores for Measures of Attention, Processing Speed, Memory, Delayed Recall, Executive Function) |
48.15; 46.70 | <.05 sig |
Summary
Alcohol Use Disorders (AUDs) have a significant public health impact and are highly prevalent in Veterans. Alcohol related brain effects on neurocognition (attention, memory and executive function) reduce ability to benefit from current treatments. These cognitive impairments are especially common in the early phase of recovery, persist over years and get worse with age. Recent research suggests that cognitive remediation therapy (CRT) may improve attention, memory and executive function in other disorders, and the investigators just completed pilot study with AUD Veterans found significantly greater improvements for those receiving CRT. The proposed study examines AUD outcomes and neurocognitive improvements when CRT is combined with a standardized alcohol treatment. The investigators hypothesize that CRT will improve neurocognition and AUD outcomes more than standardized alcohol treatment alone. Findings will determine whether CRT augmentation can benefit Veterans with AUDs.
Eligibility Criteria
Inclusion Criteria
- Veterans enrolled in VA AUD treatment as usual and Non-Veteran community members in AUD treatment
- Have a primary diagnosis of AUD and are within 30 days of detoxification or last use at time of recruitment
Exclusion Criteria
- Other medical illnesses that compromise neurocognition
- Active use of prescribed opioids or benzodiazepines that may hinder new learning
- Commitment to complete active phase and attend follow-up
- No pending incarceration or plans to leave the state
Data sourced from ClinicalTrials.gov (NCT02664038). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.