Phase 4 N=60 Randomized Quadruple-blind Treatment

Geriatric Ketamine for Pain Management Study

Pain

Bottom Line

View on ClinicalTrials.gov: NCT02673372 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2019

Primary outcome: Primary: Reduction of Pain Score at 30 Minutes — 4.4; 4.2 score on a scale

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Morphine (Drug); Ketamine (Drug)
Age: Older Adult · 65+ yrs
Sex: All
Sponsor: Antonios Likourezos
Primary completion: Feb 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Reduction of Pain Score at 30 Minutes	4.4; 4.2	—

Summary

This research project is geared towards geriatric analgesia in the Emergency Department (ED) with a goal of reducing the administration of opioid pain medications to elderly patients, thereby avoiding the commonly occurring, severe side effects associated with such medications, including hypotension, respiratory depression, altered mental status, delirium, as well as nausea/vomiting and constipation. The primary outcome of the study will be difference in pain score from baseline to 30 minutes post-medication administration. This project has the potential to change and modify the ED approach to geriatric analgesia by virtue of minimizing the use of opioid administration in elderly patients. T

Eligibility Criteria

Inclusion Criteria

ED patients; 65 years of age and older; abdominal, flank, back, traumatic chest, neck or musculoskeletal pain; capacity to give verbal or written consent.

Exclusion Criteria

ED patients 115kg, unstable vital signs (systolic blood pressure 180 mmHg; heart rate 150 beats per minute; and respirations 30 per minute), and past medical history of severe renal or hepatic insufficiency, alcohol or drug abuse or psychiatric illness; Patients with BMI>40; severe COPD

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Data sourced from ClinicalTrials.gov (NCT02673372). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.