N/A
Completed N=62
Air Pollution Study: The Effect of Ozone on the Lung
Source: ClinicalTrials.gov NCT02673775 ↗Enrolled (actual)
62
Serious AEs
0.0%
Results posted
Oct 2023
Primary outcomePrimary: Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure. — 6.823; 1.367 ratio of M2 to M1 macrophages
Summary
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure. |
6.823; 1.367 | — |
| PRIMARY Concentrations of M1 and M2 Macrophages in the Sputum 48 Hours After Exposure. |
9.783; 3.449 | — |
| PRIMARY Concentrations of M1 and M2 Macrophages in the Sputum 72 Hours After Exposure. |
4.623; 4.379 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy men and women
Exclusion Criteria
- Cardiovascular disease
- Respiratory disease
- Diabetes
- Pregnancy
- HIV infection
- History of smoking within the last 5 years
- Daily use of antioxidant supplements (e.g., Vitamin C/E, selenium, beta-carotene, lycopene, lutein, zeaxanthin, or ginkgo biloba)
- Orthopedic or rheumatological conditions that would interfere with cycle use
Data sourced from ClinicalTrials.gov (NCT02673775). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.