N/A N=62 Air Pollution Study: The Effect of Ozone on the Lung
Air Pollution
Primary: Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure. — 6.823; 1.367 ratio of M2 to M1 macrophages
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=33 Reducing Particulate Matter-associated Cardiovascular Health Effects for Seniors
Cardiometabolic Health
Primary: Systolic Blood Pressure — 127.0; 126.5 mm Hg — p=0.588
N/A N=2,123 Effect of Air Pollution on the Cognitive Function of Adolescents
Attention Impaired · Risk-Taking · Risk Behavior
Primary: Response Speed Consistency Throughout the Attention Network Task-Flanker Task (Post ANT) — 161.3; 160.2 ms — p=0.52
N/A N=60 Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Asthma
Primary: Spirometry, Percentage Change in FEV1 From Baseline — -1.0; -4.8; -2.2; -7.4 percentage change in FEV1 from baseline — p=<0.05
N/A N=23 Effects of Reducing Indoor Air Pollution on the Adult Asthmatic Response
Asthma
Primary: PM2.5 Concentration (ug/m^3) — 18.95; 32.73 ug/m^3
N/A N=70 Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
Oxidative Stress · Inflammation · Blood Pressure
Primary: Biomarkers of Antioxidant Activity-Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) — 6.09; 5.80; 364.34; 356.59 U/ml
N/A N=9 Residential Cleaning of Indoor Air to Protect COPD Patients
Chronic Obstructive Pulmonary Disease
Primary: Mean Change in St. George Respiratory Questionnaire — -12.5; -0.45 score on a scale
N/A N=39 DRIIVE (Data and Research on Interventions to Improve the Vehicular Environment)
Vehicular Environment
Primary: Collect Preliminary Data on In-vehicle Excess Particulate Matter (PM) Exposure
N/A N=77 Reducing Traffic Pollution Exposure Improves Blood Pressure
Air Pollution
Primary: Systolic Blood Pressure (SBP) — 122.3; 120.83; 119.9 mmHg
N/A N=35 Intervention Study on the Health Impact of Air Filters in Chinese Adults
Inflammation · Coagulation · Blood Pressure
Primary: Circulating Biomarkers — 926.3; 913.1; 1122.2; 1108.2 ng/ml
N/A N=225 Improving the Behavioural Impact of Air Quality Alerts
Pollution; Exposure · Health Behavior
Primary: Adoption of Protective Behaviour at 4 Weeks — 3.67; 4.25; 4.29; 3.65 units on a scale 1-9 — p=.964
N/A N=120 Motivational Interviewing and Air Cleaners for Smokers With COPD (MOVE COPD)
COPD, Chronic Obstructive Pulmonary Disease
Primary: Change in Quality of Life -St. George's Respiratory Questionnaire (SGRQ) — -2.9; 1.5 score on a scale — p=0.025
N/A N=40 AQI and Childhood Asthma: an Intervention
Asthma · Asthma in Children
Primary: Number of Participants With at Least One Moderate or Severe Asthma Exacerbation Over Time — 5; 4; 13; 12 Participants — p=0.32
N/A N=60 Health Effects of Indoor Air Filtration in Healthy Chinese Adults
Blood Pressure
Primary: Changes of Serum Cortisol Levels — 0.012835; 0.016206 relative intensity — p=<0.05
N/A N=20 Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ozone Exposure During Rest and Exercise
Primary: Time-to-exhaustion on Maximal Cycling Bout — 209; 235 seconds — p=0.092
N/A N=64 Home Air Quality Impact for Adults With Asthma
Asthma · Environmental Exposure · Home Environment Related Disease
Primary: Episodes Per Day — 2.22 Episodes per day
N/A N=28 Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
Autonomic Nervous System Imbalance · Blood Pressure · Inflammation
Primary: Heart Rate Variability-LF Power,HF Power,VLF Power — 899.4; 838.5; 519.7; 416.6 ms^2 — p=<0.05
N/A N=46 Cleaner Air for Better Cardiac Biomarkers
Cardiovascular Diseases
Primary: Percent Change in Circulating Concentration of Tumor Necrosis Factor Alpha (TNFα) — -1.03; 2 percent change
Phase 2 N=170 Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants
Environmental Carcinogenesis
Primary: Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples — 24.8; 11.0; 4.3 micromoles/24 hours — p=<0.001
N/A N=29 Environmental Intervention to Reduce Allergens in Urban Schools and Childhood Asthma
Asthma
Primary: Asthma Symptoms — 1.5; 2.9; 1; 0.4 Days
Phase 4 N=18 Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)
Asthma and/or Exercise Induced Bronchoconstriction · Ozone Air Pollution
Primary: Measured Before and 30 Minutes After Exercise in Each 1 Day Condition — 6.98; 5.96; -1.38; -.35 litres
N/A N=38 Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose
Allergic Airway Disease
Primary: Total Nasal Cell Count in Response to DEP Challenge at 0, 6 and 24 hr With or Without BSE Intervention — 4.44; 4.50; 4.73; 4.70 log cells/mL — p=<0.001
N/A N=351 Allergens in Inner-City Schools and Childhood Asthma
Asthma
Primary: Maximum Symptom Days/14 Days — 2.7 days
N/A N=299 Nucleophilic Defense Against PM Toxicity (NEAT Trial)
Air Pollution Toxicity
Primary: Endothelial Progenitor Cells — 0.0025; 0.0027 # cells per CD41 minus cells
N/A N=330 PRIDE: Preventing Respiratory Illnesses During Childhood Study
Tobacco Smoke Pollution
Primary: Air Nicotine Levels — 1.17; 0.58; 0.71; 0.51 mg/m^3
N/A N=523 Wood Stove Interventions and Child Respiratory Health
Lower Tract Respiratory Infection
Primary: Number of Participants With at Least One LRTI During Follow-up Period — 16; 20; 17; 138 Participants — p=0.68
N/A N=143 Wood Smoke Interventions in Native American Populations
Respiratory; Disorder, Functional, Impaired · Respiratory Infection Other
Primary: Post-intervention FEV1 — 1.9; 2.1; 2.0 liters — p=0.10
N/A N=25 Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers
Mild Asthma
Primary: Post Ozone Change in Lung Function (FEV1) Between Subjects With GSTM1 Null Genotype Compared to GSTM1 Sufficient Subjects — 85; 79 percentage of FEV1 predicted
N/A N=10 Circadian Rhythm Disruption Effects on Smoke Inhalation
Inflammation · Sleep Deprivation · Circadian Rhythm Sleep Disorder, Shift Work Type
Primary: Blood Inflammation — 0.69; 0.79; 2.33; 1.63 pg/mL — p=<0.05
Phase 2 N=12 Woodsmoke Particulate + Prednisone
Airway Inflammation
Primary: Change From Baseline to 4 Hours in Sputum Percent Neutrophils — -2.62; 5.45 percent neutrophils — p=0.24