Phase 4
Completed N=40
Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy
Source: ClinicalTrials.gov NCT02684942 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Jun 2017
Primary outcomePrimary: Pain Score — 0.04; 0.14; 0.49; 0.40 units on a scale
◆ Published Evidence
Established
43citations · ~2 / year
Midazolam and pethidine versus propofol and fentanyl patient controlled sedation/analgesia for upper gastrointestinal tract ultrasound endoscopy: a prospective randomized controlled trial.
Summary
Purpose: To compare the pain level and quality of life of the two sedation regimens consisting of diazepam in combination with meperidine or fentanyl.
Materials and methods: A total of 40 patients (160 sessions of brachytherapy), unselected brachytherapy out patients at Chulabhorn Hospital, Thailand were enrolled with informed consent and randomized to receive meperidine or fentanyl. Data of perceived pain (according to standard 10-cm visual analog scales [VAS]), and perceived Quality of life (EQ-5D) were collected. Patients and all brachytherapy staffs directly involved with the procedure were blinded about the drug used.
Linked Publications (2)
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Midazolam and pethidine versus propofol and fentanyl patient controlled sedation/analgesia for upper gastrointestinal tract ultrasound endoscopy: a prospective randomized controlled trial.
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Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Score |
0.04; 0.14; 0.49; 0.40; 0.59; 0.65 | — |
| SECONDARY Quality of Life |
62; 58; 16; 18; 1; 1 | — |
Eligibility Criteria
Inclusion Criteria
- Aged 20 years old or older,
- Diagnosed with cervical cancer
- On course of external Radiation therapy
- Treated with brachytherapy 4 times.
Exclusion Criteria
- Pregnant
- Previously underwent intracavitary brachytherapy
- Illiterate
Data sourced from ClinicalTrials.gov (NCT02684942) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.