N/A
Completed N=34
Ketamine for Acute Migraine in the Emergency Department
Source: ClinicalTrials.gov NCT02697071 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Feb 2021
Primary outcomePrimary: Achievement of Pain Response After Ketamine Dose. — 2.0; 1.0 change in score on a scale
Summary
This research study will be a prospective, randomized, double-blind, placebo-controlled trial. Because ketamine has yet to be directly studied as treatment for acute migraine headache in the emergency department, the research team is initially interested if ketamine can reduce pain scores in headache patients and reduce the incidence of recurrence while exhibiting an adequate safety profile. By using a placebo-controlled study design, the research team can adequately investigate the effectiveness of the medication in a subgroup previously not well studied.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Achievement of Pain Response After Ketamine Dose. |
2.0; 1.0 | — |
| SECONDARY Categorical Pain Score Change From Baseline |
0.72; 0.56 | — |
Eligibility Criteria
Inclusion Criteria
- 18-65 years of age
- Chief complaint of headache
- International Classification of Headache Disorder classification of migraine or probable migraine with or without aura
- Has decision making capacity
- Consent
- Provider determination of non-emergent cause
Exclusion Criteria
- Over the age of 50 with first time headache
- Known adverse reaction or tolerance to study medication
- Headache due to trauma
- New onset, focal, abnormal, neurologic findings
- New onset seizures
- History of metastatic cancer or neoplasm
- Active psychotic symptoms
- Altered mental status
- Provider intends to preform lumbar puncture
- Pregnancy
- Breast feeding
- Previous enrollment in study
- Fever > 100.3 F
- Physiologic instability (blood pressure 170/100, heart rate 120, chronic respiratory, renal or hepatic failure)
- Suspected cardiac pain
Data sourced from ClinicalTrials.gov (NCT02697071). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.