N/A
N=102
Palliative Radiation Therapy in Reducing Pain in Patients With Bone Metastasis
Malignant Neoplasm · Metastatic Malignant Neoplasm in the Bone · Pain
Bottom Line
View on ClinicalTrials.gov: NCT02699697 ↗Enrolled (actual)
102
Serious AEs
54.9%
Results posted
Dec 2025
Primary outcome: Primary: Re-Treatment Rates - Arm 1 (8 Gy x 1) vs. Arm 2 (8 Gy x 2) — 3; 3; 19; 17 Participants — p=0.8325
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- External Beam Radiation Therapy (Radiation); Palliative Radiation Therapy (Radiation); Quality-of-Life Assessment (Other); Questionnaire Administration (Other)
- Age
- Pediatric, Adult, Older Adult
- Sex
- All
- Sponsor
- Wake Forest University Health Sciences
- Primary completion
- Mar 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Re-Treatment Rates - Arm 1 (8 Gy x 1) vs. Arm 2 (8 Gy x 2) |
3; 3; 19; 17 | 0.8325 |
| SECONDARY Change in Pain Intensity Assessed Using the Numerical Rating Pain Scale NRPS - Continuous Scale |
4.4; 3.8; 4.2; 4.4 | 0.5593 |
| SECONDARY Change in Narcotic Use Assessed Using the Numerical Rating Pain Scale NRPS - Narcotic Use |
6; 9; 5; 6 | 0.3058 |
| SECONDARY Change in Quality of Life Measured Using the Quality of Life Questionnaire (QLQ) Core(C)15-palliative (PAL) |
87.0; 64.2; 65.7; 72.2; 74.0; 75.4 | 0.4182 |
| SECONDARY Incidence of Adverse Events - Grade 3 or Higher |
1; 0; 0; 0; 0; 0 | — |
| SECONDARY Participants With Patient Satisfaction of Treatment Outcome - Patient Satisfaction With Cancer Care (PSCC-18) |
25.8; 26.3; 25.4; 26.0 | 0.8444 |
| SECONDARY Participants With Perceived Stress of Treatment Outcome - Perceived Stress Scale (PSS-10) |
8.7; 8.0; 5.6; 4.7; 14.2; 13.0 | 0.6700 |
| SECONDARY Participants With Social Support Assessed Via Self-Reported Surveys |
6.5; 6.0; 5.8; 6.0; 8.1; 8.8 | 0.3784 |
Summary
This randomized phase II trial studies how well palliative radiation therapy works in reducing pain in patients with cancer that has spread from the original (primary) tumor to the bone (bone metastasis). Palliative radiation therapy using external beam radiation therapy may help patients with bone metastasis to relieve symptoms and reduce pain caused by cancer.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of cancer, not including multiple myeloma
- Radiographic evidence of bone metastases within 8 weeks of study; the patient must have pain which appears to be related to the radiographically documented metastasis in the opinion of the treating physician, and the decision has been made by the responsible clinician that a course of palliative external beam radiation therapy is appropriate treatment; multiple sites eligible if they can be included in no greater than 3 treatment sites
- Eligible treatment sites are:
- Weight bearing sites
- Pelvis (excluding pubis)
- Femur
- Sacrum and/or sacroiliac joints
- Tibia
- Non-weight bearing sites
- Up to 5 consecutive cervical, thoracic or lumbar vertebral bodies
- Lumbosacral spine
- Up to 3 consecutive ribs
- Humerus
- Fibula
- Radius ± ulna
- Clavicle
- Sternum
- Scapula
- Pubis If multiple sites are treated, the treatment site is included as weight-bearing if any of the sites include the pelvis, sacrum, femur or tibia
- Pain score of at least 5 on a scale of 0 - 10 within a week of enrollment OR pain score = 60 mg of morphine (or equivalent) per day
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 3
- Ability to understand and the willingness to sign an Institutional Review Board (IRB)-approved informed consent document
- Negative pregnancy test at study registration
- Changes in systemic chemotherapy, hormonal therapy or the use of bisphosphonates for 4 weeks before and after the delivery of radiotherapy are allowed, but recording and accounting for this in the statistical analysis is required
- Life expectancy of at least 12 weeks as deemed by the treating oncologist
- Patients will be eligible for treatment of multiple osseous sites only if those sites can be included in no more than three treatment sites; for patients with painful metastases that are contiguous but do not fit into the definition of a site listed above, those patients will still be eligible but will be considered to have two treatment sites; for example, a patient with a lesion of T4, T7 and T9 would be eligible but would be considered as two treatment sites since more than five consecutive vertebral bodies would be treated; these lesions could be treated with one field, even though the treatment is coded as two sites
Exclusion Criteria
- Previous radiotherapy or palliative surgery to the painful site
- Metastases to the skull, hands, feet are not eligible treatment sites
- Spinal cord or cauda equine compression/effacement in vertebral metastases with neurological symptoms other than just pain
Data sourced from ClinicalTrials.gov (NCT02699697). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.