N/A
Completed N=51
Effects of Combined rTMS and Treadmill Training in People With Parkinson's Disease
Source: ClinicalTrials.gov NCT02701647 ↗Enrolled (actual)
51
Serious AEs
0.0%
Results posted
Oct 2019
Primary outcomePrimary: Fastest Walking Speed — 149.5; 153.1; 156.1; 164.3 cm/s
Summary
The purpose of this study is to investigate whether the beneficial effect of treadmill training on people with Parkinson's disease can be enhanced by high- and low-frequency repetitive transcranial magnetic stimulation (rTMS).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Fastest Walking Speed |
149.5; 153.1; 156.1; 164.3; 167.3; 160.7 | — |
| SECONDARY Timed-Up-and-Go Test (iTUG) |
20.8; 18.3; 19.3; 18.4; 17.1; 18.0 | — |
| SECONDARY the Motor Section of Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) |
27.9; 27.1; 29.7; 19.9; 22.2; 27.9 | — |
| SECONDARY Walking Distance in a 2 -Minute Walk Test |
147.4; 144.7; 148.7; 160.4; 164.9; 157.3 | — |
| SECONDARY Mini Balance Evaluation Systems Test Scores |
21.5; 21.8; 21.7; 24.2; 23.8; 22.4 | — |
| SECONDARY Dual-task Timed-Up-and-Go Test (DT-TUG) |
27.9; 24.0; 25.5; 23.1; 21.1; 23.4 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosed with idiopathic Parkinson's disease by a neurologist
- had been stable on anti-Parkinsonian medication
- able to walk independently for 30 meters
Exclusion Criteria
- severe co-morbidity that may interfere with their ability to participate including significant orthopaedic or rheumatological conditions or disorders of peripheral nervous systems that may interfere with mobility or balance performance
- a diagnosis of neurological disease other than PD
- a history of psychiatric disorders
- the impossibility of inducing motor evoked potentials (MEPs)
- a score of less than 24 on the Mini-Mental State Examination
- contraindication to TMS including personal or family history of seizure disorder, metal in the head, implants of medical devices such as cardiac pacemakers or medical pumps, females subjects who are pregnant, a history of neurosurgery
- subjects with irrepressible tremor and / or dyskinesia
Data sourced from ClinicalTrials.gov (NCT02701647). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.