N/A
N=41
Near Infrared Spectroscopy Cortical Response to Noxious and Auditory Stimuli in Subjects Under General Anesthesia
Anesthesia · Pain
Bottom Line
View on ClinicalTrials.gov: NCT02703090 ↗Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcome: Primary: Changes in Cortical Oxyhemoglobin Concentrations to Ablation — 0.170; 0.057; 0.085; 0.157 μM
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Remifentanil (Drug); Normal saline (Drug)
- Age
- Pediatric, Adult · 12+ yrs
- Sex
- All
- Sponsor
- Boston Children's Hospital
- Primary completion
- Mar 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in Cortical Oxyhemoglobin Concentrations to Ablation |
25.196; 15.706; 15.634; 25.399; 15.731; 15.634 | — |
| PRIMARY Changes in Cortical Oxyhemoglobin Concentrations to Ablation |
25.196; 15.706; 15.634; 25.399; 15.731; 15.634 | — |
| PRIMARY Changes in Cortical Oxyhemoglobin Concentrations to Ablation |
25.196; 15.706; 15.634; 25.399; 15.731; 15.634 | — |
Summary
The primary aim is to utilize near-infrared spectroscopy (NIRS) in patients under general anesthesia to measure changes in brain blood flow in the bilateral somatosensory cortices and the prefrontal cortices in response to noxious stimulation.
Eligibility Criteria
Inclusion Criteria
- 12-30 years of age
- Structurally normal heart
- Right-handed
- English-speaking
Exclusion Criteria
- Unable to cooperate or understand the study
- Neurologic disease
- Diabetes mellitus
- Syndrome of greater than minor severity.
- Smoker
- Scalp or hair does not permit sufficient optical light detection
- Unable to keep his/her head still for a period of 200 consecutive seconds
Data sourced from ClinicalTrials.gov (NCT02703090). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.