N/A
Completed N=46
Vestibular Stimulation in Parkinson's Disease
Source: ClinicalTrials.gov NCT02703844 ↗Enrolled (actual)
46
Serious AEs
5.0%
Results posted
Oct 2022
Primary outcomePrimary: Change From Baseline in the Nonmotor Symptom Severity Scale (NMSS) — -33.5; -2.0 change in scale total score — p=0.0089
Summary
The purpose of this study is to determine whether caloric vestibular stimulation improves symptoms of Parkinson's Disease.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in the Nonmotor Symptom Severity Scale (NMSS) |
-33.5; -2.0 | 0.0089 sig |
| SECONDARY Change From Baseline in the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II: Motor Aspects of Experiences of Daily Living |
-3.2; -0.4 | — |
| SECONDARY Change From Baseline in the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III: Motor Examination |
-8.8; -2.8 | — |
Eligibility Criteria
Inclusion Criteria
- Participants must be diagnosed with idiopathic Parkinson's Disease as defined by the UK PDS Brain Bank Criteria.
- Participants must report limitations to Activities of Daily Life (ADL, UPDRS subscale 2)
- Capacity to consent to the study
- Motivated to comply with the protocol
- An understanding of English sufficient to comply with the protocol
- Spouse/ carer willing to support the participant throughout the study
Exclusion Criteria
- Diagnosis of induced Parkinson's or essential/dystonic tremor
- Premorbid psychiatric history (including affective disorder, psychosis or deliberate self- harm)
- Previous exposure to neurostimulation
- Inner ear pathology
Data sourced from ClinicalTrials.gov (NCT02703844). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.