N/A N=46 Randomized Triple-blind Treatment

Vestibular Stimulation in Parkinson's Disease

Parkinson's Disease

Bottom Line

View on ClinicalTrials.gov: NCT02703844 ↗

Enrolled (actual)

Serious AEs

5.0%

Results posted

Oct 2022

Primary outcome: Primary: Change From Baseline in the Nonmotor Symptom Severity Scale (NMSS) — -33.5; -2.0 change in scale total score — p=0.0089

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Caloric Vestibular Stimulation (Device); Sham Caloric Vestibular Stimulation (Device)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Kent
Primary completion: Oct 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Change From Baseline in the Nonmotor Symptom Severity Scale (NMSS)	-33.5; -2.0	0.0089 sig
SECONDARY Change From Baseline in the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II: Motor Aspects of Experiences of Daily Living	-3.2; -0.4	—
SECONDARY Change From Baseline in the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III: Motor Examination	-8.8; -2.8	—

Summary

The purpose of this study is to determine whether caloric vestibular stimulation improves symptoms of Parkinson's Disease.

Eligibility Criteria

Inclusion Criteria

Participants must be diagnosed with idiopathic Parkinson's Disease as defined by the UK PDS Brain Bank Criteria.
Participants must report limitations to Activities of Daily Life (ADL, UPDRS subscale 2)
Capacity to consent to the study
Motivated to comply with the protocol
An understanding of English sufficient to comply with the protocol
Spouse/ carer willing to support the participant throughout the study

Exclusion Criteria

Diagnosis of induced Parkinson's or essential/dystonic tremor
Premorbid psychiatric history (including affective disorder, psychosis or deliberate self- harm)
Previous exposure to neurostimulation
Inner ear pathology

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02703844). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.