N/A N=100 Randomized Double-blind Treatment

Supportive and Supportive-Expressive Treatment for Depression

Major Depressive Disorder

Bottom Line

View on ClinicalTrials.gov: NCT02728557 ↗

Enrolled (actual)

100

Serious AEs

0.0%

Results posted

Jan 2025

Primary outcome: Primary: Hamilton Rating Scale for Depression (HRSD) — 12.32; 12.06; 20.20; 20.08 units on a scale — p=.016

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Supportive-Expressive Therapy (Behavioral); Supportive Therapy (Behavioral)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of Haifa
Primary completion: Feb 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY Hamilton Rating Scale for Depression (HRSD)	12.32; 12.06; 20.20; 20.08	.016 sig
SECONDARY Beck Depression Inventory (BDI)	16.62; 13.36; 27.55; 25.76	—
SECONDARY Outcome Questionnaire (OQ)	32.26; 26.33; 73.435; 69.519	—

Summary

This study will assign patients to two types of psychotherapies in treating people with a major depression disorder, expressive versus supportive techniques, and will examine their ability to benefit from treatment based on their attachment orientation. This is a four month protocol, with a year follow up period, will compare patients receiving supportive-expressive treatment with either expressive focus or supportive focus.

Eligibility Criteria

Inclusion Criteria

Meeting MDD diagnostic criteria using the structured clinical interviews for DSM-V and scoring more than 14 on the 17-item Hamilton rating scale for depression at two evaluations (one week apart).
If on medication, patients' dosage must be stable for at least three months prior to entering the study, and they must be willing to maintain stable dosage for the duration of treatment
Age between 18 and 60
Hebrew language fluency
Provision of written informed consent.

Exclusion Criteria

Current risk of suicide or self-harm
Current substance abuse disorders
Current or past schizophrenia or psychosis, bipolar disorder, or severe eating disorder requiring medical monitoring
History of organic mental disease
Currently in psychotherapy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02728557). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.