N/A N=159 Randomized Treatment

Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA

Total Knee Arthroplasty · Osteoarthritis · Post Operative Pain Control

Bottom Line

View on ClinicalTrials.gov: NCT02730728 ↗

Enrolled (actual)

159

Serious AEs

0.0%

Results posted

Jun 2018

Primary outcome: Primary: Patients With Severe Pain at 48 Hours After Surgery — 21; 14; 12 percentage of patients with severe pain

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: 20ml bolus of 0.5% ropivicaine (Drug); 0.2% Ropivicaine at 8 milliliter/hour (Drug); 5ml bolus of 0.5% ropivicaine (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Pennsylvania
Primary completion: Jun 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Patients With Severe Pain at 48 Hours After Surgery	21; 14; 12	—
SECONDARY Pain Scores at 48 Hours After Surgery	5; 4.3; 3.9	—
SECONDARY Functional Recovery After Surgery	155; 150; 200	—
SECONDARY Patient-oriented Outcomes	12; 13; 13	—

Summary

The purpose of this study is to compare a single shot block, 24 hours, and 48 hour continuous catheter nerve block done via the adductor canal method in adult patients who have under gone total knee arthroplasty. Visual analogue scores, opioid consumption, time to up and go, ambulation, manual muscle tests, and Tinetti scores up to 72 hours post operatively will be used for comparison.

Eligibility Criteria

Inclusion Criteria

Patients scheduled for primary total knee arthroplasty
American Society of Anesthesiologists (ASA) physical status I -III
mentally competent and able to give consent for enrollment in the study

Exclusion Criteria

Patient younger than 18 years old
Allergy to local anesthetics, systemic opioids (fentanyl, morphine, hydromorphone, and any of the drugs included in the multimodal perioperative pain protocol (MP3)
Revision surgery
Impaired kidney functions and patient with coagulopathy
Chronic pain syndromes; Patients will be defined to have chronic pain if they are using regular daily doses of systemic narcotics for the past 3 months prior to the surgery
BMI of 40 or more
Pregnancy (positive urine pregnancy test result in Preop area on morning of surgery)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02730728). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.