Phase 4
Completed N=42
Clopidogrel Versus Ticagrelor in Type-2 Diabetes
Source: ClinicalTrials.gov NCT02742987 ↗Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Aug 2017
Primary outcomePrimary: Flow-mediated Dilation of the Brachial Artery — 16.6; 11.6 FMD (%)
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
CLOTILDIA is a single-center, prospective, randomized, open label, cross-over study evaluating the effects of ticagrelor versus high-dose clopidogrel on endothelial function and platelet reactivity in patients with type-2 diabetes mellitus (T2DM) treated with percutaneous coronary intervention (PCI).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Flow-mediated Dilation of the Brachial Artery |
16.6; 11.6 | — |
| SECONDARY Number of Patients With Flow-mediated Dilation of the Brachial Artery <7% |
— | — |
| SECONDARY Endothelium-independent Dilation of the Brachial Artery |
— | — |
| SECONDARY Platelet Reactivity |
— | — |
| SECONDARY Number of Patients With Platelet Reactivity >256 P2Y12 Reaction Units |
— | — |
Eligibility Criteria
Inclusion Criteria
- type 2 diabetes mellitus
- stable coronary disease
- coronary revascularization with PCI at least 1 month prior to recruitment
Exclusion Criteria
- acute coronary syndrome
- platelet count <70x109/l
- active bleeding or bleeding diathesis
- history of intracranial bleeding
- gastrointestinal bleeding <6 months
- cerebrovascular accident <3 months
- history of malignancy
- concomitant need for oral anticoagulant therapy
- severe liver disease or chronic renal failure (glomerular filtration rate <30 ml/min /1.73m2)
Data sourced from ClinicalTrials.gov (NCT02742987). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.