N/A
N=6,030
Optimizing Electronic Alerts for Acute Kidney Injury
Acute Kidney Injury
Bottom Line
View on ClinicalTrials.gov: NCT02753751 ↗Enrolled (actual)
6,030
Serious AEs
0.0%
Results posted
Feb 2022
Primary outcome: Primary: Composite of Progression of AKI, Inpatient Dialysis, or Inpatient Death — 622; 653 Participants — p=0.67
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- AKI Alert (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Jan 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Composite of Progression of AKI, Inpatient Dialysis, or Inpatient Death |
622; 653 | 0.67 |
| SECONDARY Mortality |
265; 272 | — |
| SECONDARY Dialysis |
93; 106 | — |
| SECONDARY AKI Progression |
461; 487 | — |
| SECONDARY AKI Duration |
2108; 2239; 722; 700; 141; 120 | — |
| SECONDARY Readmission Rate |
— | — |
| SECONDARY Index Hospitalization Cost |
10300; 10600; 19100; 20100 | — |
| SECONDARY Proportion of AKI "Best Practices" Achieved Per Subject During Index Hospitalization |
1034; 1174; 339; 397; 444; 519 | — |
| SECONDARY Number of Subjects With Chart Documentation of AKI |
1871; 2141 | — |
Summary
This study will enroll hospitalized adults with acute kidney injury (AKI) and randomize them to usual care versus an electronic alert coupled to a "best practices" order set.
Eligibility Criteria
Inclusion Criteria
- Adult ≥ 18 years admitted to a participating study hospital
- Acute Kidney Injury as defined by KDIGO consensus creatinine criteria (0.3mg/dl increase in serum creatinine over 48 hours or 50% relative increase over 7 days).
Exclusion Criteria
- ESKD diagnosis code
- Dialysis order prior to AKI onset
- Initial creatinine >=4.0mg/dl
- Prior admission in which patient was randomized.
- Admission to hospice service or comfort measures only order
- Kidney transplant within 6 months
Data sourced from ClinicalTrials.gov (NCT02753751). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.