N/A
N=2,046
Learning Alerts for Acute Kidney Injury
Acute Kidney Injury
Bottom Line
View on ClinicalTrials.gov: NCT02786277 ↗Enrolled (actual)
2,046
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcome: Primary: Proportion of Patients With Progression to a Higher Stage of AKI OR Dialysis OR Death — 190; 193 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Alert (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Aug 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Proportion of Patients With Progression to a Higher Stage of AKI OR Dialysis OR Death |
190; 193 | — |
| SECONDARY 14-day Mortality |
72; 58 | — |
| SECONDARY Inpatient Mortality |
169; 185 | — |
| SECONDARY 14-day Dialysis |
38; 37 | — |
| SECONDARY Inpatient Dialysis |
39; 41 | — |
| SECONDARY Discharge on Dialysis |
28; 22 | — |
| SECONDARY Progression to Stage 2 AKI |
91; 103 | — |
| SECONDARY Progression to Stage 3 AKI |
72; 66 | — |
| SECONDARY Duration of AKI |
26.9; 27.7 | — |
| SECONDARY 30 Day Readmission Rate |
123; 187 | — |
| SECONDARY Index Hospitalization Cost |
— | — |
| SECONDARY Chart Documentation of AKI |
442; 505 | — |
| SECONDARY Proportion of AKI "Best Practices" Achieved Per Subject During Index Hospitalization |
.6; .6 | — |
Summary
The primary objective of this study is to determine whether the use of uplift (also known as Conditional Average Treatment Effect - CATE) modeling to empirically identify patients expected to benefit the most from AKI alerting and to target AKI alerts to these patients will reduce the rates of AKI progression, dialysis, and mortality.
Eligibility Criteria
Inclusion Criteria
- Adults ≥ 18 years
- Admitted to a participating hospital
- Has AKI as defined by creatinine criteria:
- 0.3 mg/dl increase in inpatient serum creatinine over 48 hours OR
- 50% relative increase in inpatient serum creatinine over 7 days
Exclusion Criteria
- Dialysis order prior to AKI onset
- Initial creatinine ≥ 4.0 mg/dl
- Prior admission in which patient was randomized
- Admission to hospice service or comfort measures only order
- ESKD diagnosis code
- Kidney transplant within six months
- Opted out of electronic health record research
Data sourced from ClinicalTrials.gov (NCT02786277). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.