N/A
Completed N=106
North Carolina Newborn Exome Sequencing for Universal Screening
Metabolism, Inborn Errors · Hearing Loss · Hereditary Disease
Source: ClinicalTrials.gov NCT02826694 ↗
Enrolled (actual)
106
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcomePrimary: Parental Choices Following Decision Aid — 120; 57; 25; 2 Participants
Summary
The NC NEXUS research study is exploring the utility of next generation sequencing in newborn screening and parental decision making. The National Institutes of Health (NICHD and NHGRI) are co-funding this study under a single U-19.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Parental Choices Following Decision Aid |
120; 57; 25; 2 | — |
| PRIMARY Number of Participants Identified With Genetic Conditions Through Whole Exome Sequencing |
61; 0; 0; 28; 0; 17 | — |
| SECONDARY Parental Reaction Scores |
2.3; 1.7; 2.5; 1.5 | 0.168 |
Eligibility Criteria
Inclusion Criteria
- Uncomplicated pregnancy and healthy newborn
Exclusion Criteria
- Abnormalities such as major malformation or chromosomal disorder detected prenatally or significant complications during pregnancy or at the time of delivery.
Data sourced from ClinicalTrials.gov (NCT02826694). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.