N/A
Completed N=10
Mechanisms of Walking Recovery After Stroke
Source: ClinicalTrials.gov NCT02858349 ↗Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Mar 2019
Primary outcomePrimary: Walking Speed — 0.13 meters per second — p=0.0042
Summary
Subjects with stroke will have behavioral testing and brain imaging before and after a 4-week control period and a 4-week exercise intervention.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Walking Speed |
— | — |
| SECONDARY Gait Symmetry |
— | — |
| SECONDARY Metabolic Cost of Gait |
— | — |
| SECONDARY Aerobic Capacity |
— | — |
| SECONDARY NIH Toolbox - Cognition Domain |
— | — |
| SECONDARY NIH Toolbox Standing Balance Test |
— | — |
| SECONDARY Stroke and Aphasia Quality of Life Scale |
— | — |
| SECONDARY Brain Locomotor Network Activation |
— | — |
| SECONDARY Brain Locomotor Network Connectivity |
— | — |
| SECONDARY Walking Capacity |
— | — |
| SECONDARY Daily Walking Activity |
— | — |
| SECONDARY Walking Speed |
— | — |
Eligibility Criteria
Inclusion Criteria
- age 30-90 years
- unilateral stroke experienced >6 months prior to enrollment in middle cerebral artery (MCA) territory without complete disruption of the putamen on the lesion side
- walking speed 2)
- recent (<3 months) illicit drug or alcohol abuse or significant mental illness
- major post-stroke depression (PHQ-9 ≥10) in the absence of medical management
- participating in physical therapy or another interventional research study;
- recent (<3 months) paretic LE botulinum toxin injection
- concurrent progressive neurologic disorder or other major medical, orthopedic or peripheral vascular conditions that would limit improvement
- pregnancy
Data sourced from ClinicalTrials.gov (NCT02858349). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.