Phase 4
Completed N=43
Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
Adverse Reaction to Spinal Anesthetic · Maternal Care for Cervical Incompetence
Source: ClinicalTrials.gov NCT02862912 ↗
Enrolled (actual)
43
Serious AEs
0.0%
Results posted
May 2020
Primary outcomePrimary: Time to Resolution of Motor Block — 109; 112 minutes
◆ Published Evidence
Established
21citations · ~5 / year
Intrathecal 2-Chloroprocaine 3% Versus Hyperbaric Bupivacaine 0.75% for Cervical Cerclage: A Double-Blind Randomized Controlled Trial.
Summary
This study aims to determine whether or not spinal anesthesia with the local anesthetic drug, chloroprocaine, wears off faster than the local anesthetic drug, bupivacaine, and results in faster discharge from the post-anesthesia care unit after surgery.
Linked Publications
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Intrathecal 2-Chloroprocaine 3% Versus Hyperbaric Bupivacaine 0.75% for Cervical Cerclage: A Double-Blind Randomized Controlled Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time to Resolution of Motor Block |
109; 112 | — |
| SECONDARY Time to Ambulate |
158; 229 | — |
| SECONDARY Time to Void |
229; 158 | — |
Eligibility Criteria
Inclusion Criteria
- ASA I and II women
- 18-45 yrs old
- Singleton pregnancy
- Cervical cerclage 1st or 2nd trimester of pregnancy undergoing with spinal anesthesia
- Height 150 - 180 cm
- BMI ≤ 40 kg/m2.
Exclusion Criteria
- Any contraindication to neuraxial anesthesia (history of neurologic disease (e.g., multiple sclerosis, spinal stenosis, central or peripheral neuropathy)
- Pre-existing/chronic back pain
- Ester local anesthetic allergy, PABA allergy
- History of atypical cholinesterase (CP is metabolized by cholinesterase)
Data sourced from ClinicalTrials.gov (NCT02862912) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.