N/A N=52 Randomized Health Services Research

Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI

Mild Cognitive Impairment

Bottom Line

View on ClinicalTrials.gov: NCT02864069 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2020

Primary outcome: Primary: Rivermead Behavioral Memory Test — 11.08; 11.2; 12.31 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Walking Intervention (Behavioral); Cognitive Training Intervention (Behavioral); Combined Intervention (Behavioral)
Age: Adult, Older Adult · 60+ yrs
Sex: All
Sponsor: University of California, San Diego
Primary completion: Oct 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Rivermead Behavioral Memory Test	11.08; 11.2; 12.31	—
PRIMARY Everyday Cognition Scale	1.50; 1.14; 1.24	—
PRIMARY Older Peoples Quality of Life Questionnaire	76.08; 72.20; 68.15	—

Summary

Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging. This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course. This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).

Eligibility Criteria

Inclusion Criteria

MCI diagnosis (can be self referral, will determine eligibility at baseline)

Exclusion Criteria

Dementia diagnosis
Head trauma
Neuro/psychiatric disorders
Current substance dependence
Sensory/mobility deficits
No more than 1 hour of purposeful, aerobic activity/week
Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02864069). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.