N/A
Completed N=133
Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock
Source: ClinicalTrials.gov NCT02884011 ↗Enrolled (actual)
133
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcomePrimary: Total Vasopressor Dose — 13.7; 13.1; 13.2; 11.3 mg
Summary
Retrospective study to examine the effects of chronic antihypertensive medications on vasopressor dosing in septic shock
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Vasopressor Dose |
13.7; 13.1; 13.2; 11.3 | — |
| SECONDARY 30 mL/kg Fluid Within 6h |
36; 27; 12; 16 | — |
| SECONDARY Inotrope Use |
— | — |
| SECONDARY Hydrocortisone Use |
— | — |
| SECONDARY Cumulative Vasopressor Dose for Patients Receiving Other Antihypertensives |
— | — |
| SECONDARY 6-hour Vasopressor Dose |
— | — |
| SECONDARY 12-hour Vasopressor Dose |
— | — |
| SECONDARY 24-hour Vasopressor Dose |
— | — |
Eligibility Criteria
Inclusion Criteria
- Adult patients 18 years of age or older
- Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin)
- Admitted to an intensive care unit (ICU) at Rush University Medical Center (RUMC)
- Time frame: 01/01/2012 to 07/1/2016
Exclusion Criteria
- Pregnant patients
- Transfer from outside hospital on vasopressors
- Admitted in cardiopulmonary arrest
- Prior arrest within 24 hours of admission to RUMC
Data sourced from ClinicalTrials.gov (NCT02884011). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.