N/A
Completed N=58
Project IMPACT: Improving Memory Performance by Applying Cognitive Training
Cocaine Use Disorders · HIV
Source: ClinicalTrials.gov NCT02909101 ↗
Enrolled (actual)
58
Serious AEs
0.0%
Results posted
Oct 2019
Primary outcomePrimary: Working Memory Assessed by Domain Deficit Score — .29; .21; .14; .26 Score on a scale — p=0.039
Summary
The purpose of this study is to examine the effects of a cognitive training program in persons with Human Immunodeficiency Virus (HIV) infection who have used cocaine. This study tests the feasibility and preliminary efficacy of a computerized cognitive training program to improve working memory and decrease impulsivity (delay discounting) among HIV-infected individuals.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Working Memory Assessed by Domain Deficit Score |
.29; .21; .14; .26 | 0.039 sig |
| SECONDARY Delay Discounting, Measured by the Monetary Choice Questionnaire (MCQ) |
8.70; 7.97; 8.38; 8.76 | 0.054 |
| SECONDARY Acceptability as Measured by Participant Ratings |
4.04; 4.14 | 0.744 |
| SECONDARY Acceptability as Measured by Participant Perception of Benefits and Barriers to Completing Sessions |
4.14; 4.04 | 0.719 |
| SECONDARY Percent Medication Adherence Across All Antiretroviral Medications |
96.53; 88.97; 96.08; 92.03 | 0.337 |
| SECONDARY Sexual Risk Behavior as Measured by the Risk Assessment Battery (RAB) |
4.53; 3.68; 4.04; 4.21 | 0.025 sig |
| SECONDARY Number of Days of Cocaine Use as Measured by Timeline Followback Interview Methodology |
7.51; 6.88; 8.49; 5.12 | 0.133 |
Eligibility Criteria
Inclusion Criteria
- HIV infection
- currently on antiretroviral medications for >3 months
- cocaine use as defined by crack/cocaine use in the past month, cocaine-type stimulant use disorder, and cocaine as the principal substance of abuse
- working memory impairment as defined by scoring >1 standard deviation below the normative mean on at least 2 out of the 3 working memory tests
Exclusion Criteria
- pregnancy
- English non-fluency or illiteracy
- <8th grade education
- serious neurological disorders including HIV dementia, traumatic brain injury, severe mental illness, or acute psychiatric distress
- impaired mental status
- individuals who state they are planning to move away from the area within the next 3 months
- individuals without stable housing
Data sourced from ClinicalTrials.gov (NCT02909101). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.