Phase 4
N=32
Intravenous Lidocaine Versus Morphine for Severe Pain in the ED
Pain
Bottom Line
View on ClinicalTrials.gov: NCT02912195 ↗Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Apr 2020
Primary outcome: Primary: Pain Score (NRS 0-10) — 5.1; 4.2 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Intravenous lidocaine (Drug); Intravenous morphine (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Alameda Health System
- Primary completion
- Sep 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Score (NRS 0-10) |
5.6; 4.6 | — |
| SECONDARY Pain Score (NRS 0-10) |
5.6; 4.6 | — |
| SECONDARY Pain Score (NRS 0-10) |
5.6; 4.6 | — |
| SECONDARY Pain Score (NRS 0-10) |
5.6; 4.6 | — |
| SECONDARY Pain Score (NRS 0-10) |
5.6; 4.6 | — |
| SECONDARY Pain Score (NRS 0-10) |
5.6; 4.6 | — |
| SECONDARY Pain Relief at 10 Minutes Compared to Baseline. |
1.1; 2.0 | — |
| SECONDARY Pain Relief at 20 Minutes Compared to Baseline. |
1.8; 2.8 | — |
| SECONDARY Pain Relief at 30 Minutes Compared to Baseline. |
2.2; 3.4 | — |
| SECONDARY Pain Relief at 40 Minutes Compared to Baseline. |
2.9; 4.2 | — |
| SECONDARY Pain Relief at 50 Minutes Compared to Baseline. |
3.6; 4.4 | — |
| SECONDARY Pain Relief at 60 Minutes Compared to Baseline. |
4.1; 4.8 | — |
| SECONDARY Number of Participants Requiring Rescue Medications |
5; 4 | — |
| SECONDARY Patient Satisfaction |
13; 14 | — |
| SECONDARY Number of Participants Reporting Adverse Events |
2; 6 | — |
Summary
Objective: Evaluate the analgesic efficacy of intravenous (IV) lidocaine versus provider chosen dose of IV morphine for the treatment of severe pain in the emergency department.
Study design: Open-label, randomized controlled pilot study.
Eligibility Criteria
Inclusion Criteria
- Subject has severe pain (NRS ≥7)
- Subject has anticipated ED stay of ≥1 hour
Exclusion Criteria
- High acuity trauma patients
- Patients deemed to critically ill by ED provider
- Active psychosis
- Pregnancy
- History of heart block or bradycardia
- Allergy to lidocaine or amide type local anesthetic
- History of seizures
Data sourced from ClinicalTrials.gov (NCT02912195). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.