N/A
N=50
Effect of Passive Ultrasonic Irrigation on the Reduction of Bacteria and Endotoxins in Root Canals
Tooth, Nonvital
Bottom Line
View on ClinicalTrials.gov: NCT02917642 ↗Enrolled (actual)
50
Serious AEs
—
Results posted
Jul 2018
Primary outcome: Primary: Bacterial Levels — 4290; 10800 DNA copies — p=0.04
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Ultrasonic Irrigation (Device); Non-Ultrasonic Irrigation (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Sao Paulo
- Primary completion
- Jul 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Bacterial Levels |
4290; 10800 | 0.04 sig |
| SECONDARY Endotoxin Levels |
6.53; 5.75 | 0.94 |
Summary
The purpose of this clinical study was to compare the effectiveness of passive ultrasonic irrigation with that of traditional syringe irrigation on the removal of bacteria and endotoxin (lipopolysaccharide [LPS]) from root canals.
Eligibility Criteria
Inclusion Criteria
- Teeth with necrotic pulps and asymptomatic apical periodontitis
Exclusion Criteria
- patients who had received antibiotics during the previous 3 months or had any general disease,
- teeth that could not be properly isolated with rubber dam,
- non-restored teeth,
- periodontal pockets depths greater than 4 mm,
- previous endodontic treatment,
- open apex,
- crown/root fracture
- root resorption or calcifications.
Data sourced from ClinicalTrials.gov (NCT02917642). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.