N/A N=16 Randomized Triple-blind Treatment

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

Primary Progressive Aphasia

Bottom Line

View on ClinicalTrials.gov: NCT02928848 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2021

Primary outcome: Primary: Aphasia Severity (WAB-AQ): Effects of Active tDCS (Baseline vs. 0 Weeks Immediately Following Stimulation) — 2.68; .87; 1.98; 2.25 score on a scale — p=0.14

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: transcranial direct current stimulation (Device)
Age: Adult, Older Adult · 45+ yrs
Sex: All
Sponsor: University of Pennsylvania
Primary completion: Mar 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Aphasia Severity (WAB-AQ): Effects of Active tDCS (Baseline vs. 0 Weeks Immediately Following Stimulation)	2.68; .87; 1.98; 2.25	0.14
SECONDARY Naming Ability (WAB Naming Subtest): Effects of Active tDCS Baseline vs. 0 Weeks Immediately Following Stimulation	.63; .11; .26; .63	.02 sig

Summary

In the present sham-controlled study, the investigators examine whether tDCS could be used to enhance language abilities (e.g., picture naming) in individuals with primary progressive aphasia (PPA) primarily characterized by difficulties with speech production.

Eligibility Criteria

Inclusion Criteria

Between the ages of 45-80
Native English speaker
Diagnosed with Primary Progressive Aphasia
Subject understands nature of study and able to give informed consent

Exclusion Criteria

Cognitive impairment of sufficient severity to preclude giving informed consent
History of seizures or unexplained loss of consciousness
Previous craniotomy or any breach of the skull
Metallic objects in the head or face other than dental braces, fillings or implants
Pacemaker or implantable cardioverter-defibrillator
Pregnant

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Data sourced from ClinicalTrials.gov (NCT02928848). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.