N/A
Completed N=16
Transcranial Direct Current Stimulation for Primary Progressive Aphasia
Primary Progressive Aphasia
Source: ClinicalTrials.gov NCT02928848 ↗
Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Jun 2021
Primary outcomePrimary: Aphasia Severity (WAB-AQ): Effects of Active tDCS (Baseline vs. 0 Weeks Immediately Following Stimulation) — 2.68; .87; 1.98; 2.25 score on a scale — p=0.14
Summary
In the present sham-controlled study, the investigators examine whether tDCS could be used to enhance language abilities (e.g., picture naming) in individuals with primary progressive aphasia (PPA) primarily characterized by difficulties with speech production.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Aphasia Severity (WAB-AQ): Effects of Active tDCS (Baseline vs. 0 Weeks Immediately Following Stimulation) |
2.68; .87; 1.98; 2.25 | 0.14 |
| SECONDARY Naming Ability (WAB Naming Subtest): Effects of Active tDCS Baseline vs. 0 Weeks Immediately Following Stimulation |
.63; .11; .26; .63 | .02 sig |
Eligibility Criteria
Inclusion Criteria
- Between the ages of 45-80
- Native English speaker
- Diagnosed with Primary Progressive Aphasia
- Subject understands nature of study and able to give informed consent
Exclusion Criteria
- Cognitive impairment of sufficient severity to preclude giving informed consent
- History of seizures or unexplained loss of consciousness
- Previous craniotomy or any breach of the skull
- Metallic objects in the head or face other than dental braces, fillings or implants
- Pacemaker or implantable cardioverter-defibrillator
- Pregnant
Data sourced from ClinicalTrials.gov (NCT02928848). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.