N/A N=37 tDCS Intervention in Primary Progressive Aphasia
Primary Progressive Aphasia · MCI · FTD
Primary: Absolute Percent Change in Written Naming (Trained Items) — 39.4; 28.4; 33.1; 20.0 absolute percent change
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=8 Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy
Primary Progressive Aphasia · PPA
Primary: Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery (OANB) — 2.3; 2.05…
N/A N=10 TMS for the Treatment of Primary Progressive Aphasia
Logopenic Variant Primary Progressive Aphasia · Non-fluent Variant Primary Progressive Aphasia · Semantic Variant Primary Progressive Aphasia
Primary: Changes in Language as Measured Through the Boston Naming Test (BNT) — 1.8; 2.5; 0.063; 0.5 Items
Phase 1 N=161 Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia
Primary Progressive Aphasia · Behavioral Variant of Frontotemporal Dementia · Frontotemporal Dementia, Behavioral Variant
Primary: Proportion of PPA Subjects That Showed Elevated Tau PET Binding Compared to Normal Controls — 3; 0; 17; 0 Participants
N/A N=3 Transmagnetic Stimulation Pilot in Primary Progressive Aphasia
Primary Progressive Aphasia
Primary: Connectivity Measures of the Left TGd, 55b, and STV Parcellations at Baseline and Post-treatment — -.06; .03; -.01 correlation
N/A N=18 Treating Primary Progressive Aphasia (PPA) Using tDCS
Primary Progressive Aphasia
Primary: Western Aphasia Battery Aphasia Quotient (WAB-AQ) — 74.4; 76.5; 72.5; 76.0 scores on a scale — p=<.05
N/A N=16 Transcranial Direct Current Stimulation for Primary Progressive Aphasia
Primary Progressive Aphasia
Primary: Aphasia Severity (WAB-AQ): Effects of Active tDCS (Baseline vs. 0 Weeks Immediately Following Stimulation) — 2.68; .87; 1.98; 2.25 score on a scale — p=0.14
N/A N=8 CB3 Pilot (Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia)
Aphasia · Primary Progressive Aphasia · Dementia
Primary: Change in Communication Confidence (CCRSA) — 64.32; 65.91; 63.00; 64.77 score on a scale
Phase 2 N=11 Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)
Primary Progressive Aphasia
Primary: Percentage of Participants Who Complete 16 Out of 20 Study Visits — 100 percentage of participants
N/A N=190 Communication Bridge 2
Primary Progressive Aphasia
Primary: Change in Communication Confidence (CCRSA) — 72.6; 72.9; 73.7; 74.5 units on a scale
N/A N=5 HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
Primary Progressive Aphasia
Primary: Determine Changes in Language Performance After Stimulation Sessions
N/A N=56 In-Home Care for Patients With PSP and Related Disorders
Progressive Supranuclear Palsy · Dementia With Lewy Bodies · Multiple System Atrophy
Primary: Change in Patient Quality of Life as Measured by the EuroQol 5-D (EQ-5D) Scale Between Baseline (Visit 1) and 1 Year (Visit 4) — 1; 0.5; 0.5; 0 units on a scale — p=0.59
Phase 2 N=90 Image Parkinson's Disease Progression Study
Parkinson's Disease
Primary: Change in Free-water Accumulation in the Substantia Nigra — 0.0009; 0.0041 arbitrary units (A.U.s)
N/A N=18 Determining Learning Ability in People With Aphasia
Aphasia
Primary: SRT Observational Learning Ability — -0.03 Cohen's d
N/A N=58 Speech, Linguistic and Acoustic Markers in Parkinson's Disease
Parkinson Disease · Cognitive Impairment, Mild · Speech
Primary: Mild Cognitive Impairment — 25; 0; 23; 9 Participants
N/A N=16 Word Retrieval in the Wild in People With Post-Stroke Aphasia
Aphasia, Acquired
Primary: Change in Protocol Compliance — 67.35; 86.98 Percent response/n scheduled prompts — p=0.021
N/A N=28 Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia
Aphasia
Primary: Speech Production — 5.27; 5.28 % change score of untrained real words
N/A N=17 Assessing an Animal-Assisted Treatment Program for Adults With Aphasia: The Persons With Aphasia Training Dogs Program
Aphasia
Primary: Assessment of Living With Aphasia (ALA, Kagan et al., 2010) — 2.67; 2.33; 2.68; 2.43 units on a scale
N/A N=38 Age-related Hearing Loss and Lexical Disorders
Alzheimer Disease · Presbycusis · Lexical Syntactic Disorder
Primary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale
N/A N=58 Speech Therapy for Aphasia: Comparing Two Treatments
Stroke
Primary: Spoken Word Production (Confrontation Naming) — 53.01; 50.37 percent correct
Phase 2 N=80 Speech Entrainment for Aphasia Recovery
Aphasia · Aphasia Non Fluent · Stroke
Primary: Average Verbs Per Minute (VPM) Change From Baseline — 0.3; 0.62; -0.26; 0.52 verbs per minute
N/A N=4 A Novel Treatment for Aphasia and Apraxia of Speech : Measurement of Outcomes
Apraxia of Speech · Aphasia
Primary: Change in Language Content Production for Treated Stimuli: Effect Sizes (Magnitude of Change From Baseline to Follow-up) — 13.38 units on a scale
N/A N=11 Stepped Care for Aphasia
Aphasia · Stroke
Primary: Change in the Depression Score on Hospital Anxiety and Depression Scale at Post-Intervention — 2.2 units on a scale — p=< .05
Phase 1 N=29 Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
Progressive Supranuclear Palsy · Corticobasal Degeneration
Primary: Flortaucipir Imaging in PSP, CBD and Healthy Volunteers — 1.17; 1.12; 1.03; 1.15 standardized uptake value ratio (SUVr)
N/A N=60 Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
Post-stroke Depression · Post-stroke Aphasia
Primary: Change in Beck's Depression Inventory, BDI. — -12.6; -5.8 score on a scale
Phase 2 N=14 Treating Intention In Aphasia: Neuroplastic Substrates
Aphasia · Cerebrovascular Accident
Primary: Lateralization of Frontal Lobe (and Posterior Perisylvian) Activity During Word Production — -0.2802; -0.1832 laterality index — p=<.05
Phase 2 N=27 Practice Effects and Amyloid Imaging Using 18F-PIB or Flutemetamol PET and FDG-PET
Alzheimer's Disease
Primary: Amyloid Deposition Obtained on a 18F-flutemetamol Brain Scan. — 1.65 ratio of flutemetamol absorbed — p=<0.05
N/A N=20 Adapting Acceptance and Commitment Therapy for Stroke Survivors With Aphasia
Stroke · Aphasia
Primary: Mean Scores on the Client Satisfaction Questionnaire - 8 — 29.7 score on a scale
N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
N/A N=60 Neocortical Epilepsies - Do They Progress?
Epilepsy
Primary: Functional Connectivity