N/A
N=90
Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder
Alcohol Use Disorder · PTSD · Cognitive Dysfunction
Bottom Line
View on ClinicalTrials.gov: NCT02929979 ↗Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Feb 2021
Primary outcome: Primary: The Revised Hopkins Verbal Learning Test — 47.71; 44.14 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Cognitive Training (Behavioral); Cognitive training placebo control (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jul 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Revised Hopkins Verbal Learning Test |
47.71; 44.14 | — |
| PRIMARY The Wechsler Adult Intelligence Scale-IV Working Memory Index |
102; 103.27 | — |
| PRIMARY The Conners' Continuous Performance Task II |
47.92; 50.11 | — |
| PRIMARY The Color-Word Interference Test (DKEFS) |
10.86; 10.55 | — |
| PRIMARY The Iowa Gambling Task |
760.65; -371.40 | — |
| PRIMARY Trail Making Test (TMT) - Part B |
51.00; 49.93 | — |
| PRIMARY The Wisconsin Card Sorting Test - Computer Version 4 Research Edition |
48.65; 51.38 | — |
| PRIMARY The Tower Test (DKEFS) |
11.83; 11.00 | — |
| SECONDARY Functional Status - Inventory of Psychosocial Functioning |
40.41; 40.94 | — |
| SECONDARY PTSD Symptom Severity |
36.04; 40.64 | — |
Summary
The project will examine whether a computerized neuroscience-based cognitive training program can improve cognitive functioning and recovery outcomes among Veterans with Alcohol Use Disorder and co-occurring PTSD. Information from this study will help determine the malleability of cognitive dysfunction, an established risk factor for poor recovery outcomes in this population. Improved functional outcomes can decrease risk of chronic impairment and ultimately help affected individuals live richer, more productive lives. Web-based treatment technologies may increase the reach and impact of treatment, and foster patient recovery in cases where staffing, space, acceptability of counseling, and transportation are barriers. Findings may also support expanding use of existing, highly-accessible cognitive remediation technologies to other vulnerable clinical populations.
Eligibility Criteria
Inclusion Criteria
- Be a Veteran
- Meet DSM-5 diagnostic criteria for current AUD
- Meet DSM-5 criteria for current PTSD
- Be willing to perform daily home-based computer exercises for 6 weeks
Exclusion Criteria
Individuals will be excluded based on evidence of the following:
- History of, or current, psychotic disorder or Schizophrenia
- Current scheduled (i.e., daily) prescribed use of cognitive enhancers (e.g., Memantine) or stimulants (e.g., Methylphenidate) that may enhance cognitive performance
- Current severe traumatic brain injury (DoD TBI Screen 2)
- Any type of dementia (Mini Mental Status Exam (MMSE) < 24), delirium or medical illnesses associated with potential cognitive issues (HIV, Hypothyroidism, B-12 deficiency)
- Any level of mental retardation (Wechsler Test of Adult Reading WTAR)
- Limited ability to speak/read/write/understand English (WTAR)
- Inadequate vision or hearing
- Active suicidal/homicidal intent
- Self-report and collateral history from medical record/primary care physician/outpatient addiction treatment team will be used as necessary to determine inclusion and exclusion.
- Suicidal and homicidal intent will be assessed in the context of a structured clinical interview.
- In the unlikely event that respondents endorse active intent they will be referred immediately for treatment and will be excluded from the current study.
Data sourced from ClinicalTrials.gov (NCT02929979). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.