N/A
N=21
Probiotic Yogurt Supplement in Reducing Diarrhea in Patients With Metastatic Kidney Cancer Being Treated With Vascular Endothelial Growth Factor-Tyrosine Kinase Inhibitor
Diarrhea · Metastatic Renal Cell Carcinoma · Stage IV Renal Cell Cancer
Bottom Line
View on ClinicalTrials.gov: NCT02944617 ↗Enrolled (actual)
21
Serious AEs
0.0%
Results posted
Apr 2023
Primary outcome: Primary: Number of Participants With Overall Response — 2; 1 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Laboratory Biomarker Analysis (Other); Micronutrient-Fortified Probiotic Yogurt (Dietary_supplement); VEGF-TKI (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- City of Hope Medical Center
- Primary completion
- Dec 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Overall Response |
2; 1 | — |
| PRIMARY Number of Participants With Diarrhea |
4; 4 | 1.00 |
| SECONDARY Clinical Benefit Rate |
70; 80 | — |
| SECONDARY Progression-free Survival (PFS) |
6.2; 13.8 | 0.077 |
Summary
This randomized clinical trial studies how well probiotic yogurt supplement works in reducing diarrhea in patients with kidney cancer that has spread from the primary site to other places in the body (metastatic) and that are being treated with vascular endothelial growth factor-tyrosine kinase inhibitor therapy. Studying samples of blood and stool from patients who eat probiotic yogurt and those who avoid probiotic yogurt may help doctors plan better treatment.
Eligibility Criteria
Inclusion Criteria
- Cytologically or pathologically verified diagnosis of renal cell carcinoma (RCC)
- Diagnosis of RCC that is defined as metastatic by standard criteria (American Joint Committee on Cancer [AJCC] 7th edition, 2010)
- Planned treatment with any VEGF-TKI, treatment has not yet begun
- Ability to understand and the willingness to sign a written informed consent
- Ability to read and write English
- Documented consent to participation to include the following study specific procedures:
- Be able to provide up to six serial stool collections at home and deliver to FedEx location that day as per standard operating procedure
- Have three 10-ml blood samples taken during a routine clinic visit
- To not take probiotic supplements except as oriented
- If randomized to the probiotic-supplemented group (the yogurt-based supplement Activia), be willing to comply with daily intake and record this intake as a component of a dietary log; the patient will be asked not to take any yogurt or yogurt-containing foods beyond this
- If randomized to the probiotic-restricted group, agree not to consume yogurt or yogurt-containing foods
- Maintain a dietary log and stool frequency log
Exclusion Criteria
- Patients with a known intolerance to lactose or other constituents of Activia
- Patients with irritable bowel syndrome, Crohn's disease, or other clinically significant gastrointestinal (GI) related condition that might confound the VEGF-TKI-related-diarrhea endpoint
- Patients taking antibiotics or who plan to begin taking antibiotics
- Any other condition that would, in the investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns or compliance with clinical study procedures (including compliance issues related to feasibility/logistics)
Data sourced from ClinicalTrials.gov (NCT02944617). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.