Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Kidney Cancer

Kidney Cancer

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Kidney Cancer

205 trials tracked for Kidney Cancer: 30 in phase 3 or 4 and 19 with published results. The most-cited published study has 261 citations.

205Trials tracked
30Phase 3 & 4
0Recruiting
19With published results
Phase distribution
Phase 4 6 Phase 3 24 Phase 2 129 Phase 1 12 Other / NA 34
  1. Phase 3 Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214) Completed · 261 cited
  2. Phase 3 Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025) Completed · 240 cited
  3. Phase 3 Monoclonal Antibody Therapy (Rencarex®) in Treating Patients Who Have Undergone Surgery for Non-metastatic Kidney Cancer Completed · 146 cited
  4. Phase 3 The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study Completed · 145 cited
  5. Phase 3 Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor Completed · 140 cited
  6. Phase 3 Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor Completed · 121 cited
Show 44 more trials
  1. Phase 4 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed · 94 cited
  2. Phase 3 Sunitinib Malate or Sorafenib Tosylate in Treating Patients With Kidney Cancer That Was Removed By Surgery Completed · 85 cited
  3. Phase 3 A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC) Completed · 68 cited
  4. Phase 3 A Clinical Trial Comparing Efficacy And Safety Of Sunitinib Versus Placebo For TheTreatment Of Patients At High Risk Of Recurrent Renal Cell Cancer Completed · 60 cited
  5. Phase 3 Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Completed · 58 cited
  6. Phase 3 Mannitol Use During Partial Nephrectomy Prior to Renal Ischemia and Impact on Renal Function Outcomes Completed · 58 cited
  7. Phase 3 A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101) Completed · 58 cited
  8. Phase 3 S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery Completed · 52 cited
  9. Phase 3 A Study to Compare Tivozanib (AV-951) to Sorafenib in Subjects With Advanced Renal Cell Carcinoma Completed · 40 cited
  10. Phase 3 A Study of Avastin (Bevacizumab) Added to Interferon Alfa-2a (Roferon) Therapy in Patients With Metastatic Renal Cell Cancer With Nephrectomy Completed · 38 cited
  11. Phase 3 Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302) Completed · 24 cited
  12. Phase 3 Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Completed · 22 cited
  13. Phase 4 Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method Completed
  14. Phase 4 Safety and Efficacy of Everolimus in Metastatic Renal Cell Carcinoma After Failure of First Line Therapy With Sunitinib or Pazopanib Completed
  15. Phase 4 Study of Nivolumab for Advanced Cancers in India Completed
  16. Phase 4 A Study to Evaluate the Safety and Efficacy of Nivolumab With Ipilimumab in Participants With Untreated Advanced Kidney Cancer Conducted in India Completed
  17. Phase 4 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed
  18. Phase 3 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed
  19. Phase 3 An Extension Treatment Protocol for Subjects Who Have Participated in a Study of Tivozanib Versus Sorafenib in Kidney Carcinoma (Protocol AV-951-09-301). Completed
  20. Phase 3 Axitinib (AG-013736) For the Treatment of Metastatic Renal Cell Cancer Completed
  21. Phase 3 Study Evaluating Interferon And CCI-779 In Advanced Renal Cell Carcinoma Completed
  22. Phase 3 Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer Completed
  23. Phase 3 Pre-surgical Detection of Clear Cell Renal Cell Carcinoma (ccRCC) Using Radiolabeled G250-Antibody Completed
  24. Phase 3 Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer Completed
  25. Phase 2 Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer Completed
  26. Phase 2 A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer Completed
  27. Phase 2 Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) Completed
  28. Phase 2 Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer Completed
  29. Phase 2 Sunitinib and Erlotinib in Treating Patients With Unresectable or Metastatic Kidney Cancer Completed
  30. Phase 2 A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers Completed
  31. Phase 2 Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors Completed
  32. Phase 2 A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC) Completed
  33. Phase 2 Bupropion in Helping Adults Stop Smoking Completed
  34. Phase 2 Neoadjuvant Clinical Trial to Evaluate the Efficacy of Bevacizumab for Renal Cell Carcinoma Completed
  35. Phase 2 Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney Cancer Completed
  36. Phase 2 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed
  37. Phase 2 Vaccination of Patients With Renal Cell Cancer With Dendritic Cell Tumor Fusions and GM-CSF Completed
  38. Phase 2 Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint Inhibitors Completed
  39. Phase 2 Axitinib Given on an Individualized Schedule for Metastatic Renal Cell Cancer Completed
  40. Phase 2 Tretinoin Plus Interferon Alfa in Treating Patients With Metastatic Kidney Cancer Completed
  41. Phase 2 Evaluate Safety and Tolerability in Dose Escalation of Sorafenib in Advanced Renal Cell Cancer Completed
  42. Phase 2 Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC) Completed
  43. Phase 2 Study of Ramucirumab or Icrucumab (IMC-18F1) With Docetaxel or Docetaxel Alone as Second-Line Therapy in Participants With Bladder,Urethra, Ureter, or Renal Pelvis Carcinoma Completed
  44. Phase 2 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Completed

Showing the 50 most-cited and recently-updated of 205 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Kidney Cancer: what the trials found

Nivolumab has demonstrated significant clinical benefits in the treatment of metastatic renal cell carcinoma. In patients with intermediate/poor risk, Nivolumab showed a significantly higher objective response rate (41.6% vs 26.5%, p<0.0001), improved progression-free survival (11.56 months vs 8.38 months, p=0.0331), and superior overall survival (25.95 months vs NA, p<0.0001) 9. In another trial, Nivolumab showed a significant improvement in overall survival (25.00 vs 19.55, p=0.0018) and progression-free survival (4.21 vs 4.50, p=0.0340) 10.

Avelumab showed statistically significant improvements in progression-free survival for both PD-L1 positive participants (13.8 vs 7.2 months, p=0.0001) and all participants regardless of PD-L1 expression (13.8 vs 8.4 months, p=0.0002) 20.

Sunitinib malate demonstrated a significant improvement in disease-free survival (6.8 vs 5.6, p=0.030) when assessed by blinded independent central review 17. In contrast, Everolimus showed a progression-free survival of 2.8 to 8.0 months at 24 months following treatment after failure of first-line Sunitinib or Pazopanib 6.

Pazopanib demonstrated no significant difference in overall survival compared to placebo (89.5 vs NA, p=0.9880) 16. Sorafenib Tosylate showed no significant difference in disease-free survival (5.8; 6.1; 6.6, p=0.80) 15.

Recent results — preliminary, needs further review

  • Selenomethionine (SLM) is currently being evaluated in a Phase 2 trial 1.
  • Carevive software was evaluated for usability and plan utilization, with 73% of surveys completed and 36% of auto-generated plans utilized 2.

For the clinician treating this condition

  • Nivolumab is supported by multiple trials showing significant improvements in progression-free survival and overall survival in metastatic renal cell carcinoma patients.
  • Avelumab demonstrated statistically significant improvements in progression-free survival regardless of PD-L1 expression status.
  • Sunitinib malate showed a statistically significant improvement in disease-free survival based on independent central review.

AI synthesis of 9 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Contrast-enhanced ultrasound shows 0.95 accuracy in distinguishing malignant from benign renal masses
Oncology Meta-analysis
Contrast-enhanced ultrasound shows 0.95 accuracy in distinguishing malignant from benign renal masses Ultrasound imaging helps doctors tell kidney cancer from benign masses
This meta-analysis of 4,530 renal masses evaluated the diagnostic accuracy of contrast-enhanced ultrasound (CEUS). The analysis found a sens…
A new look at ultrasound imaging shows it can accurately distinguish between cancerous and non-cancerous kidney masses.
Sep 25, 2026
MITF E318K variant associated with significantly increased melanoma risk and high nevus burden
Oncology Meta-analysis
MITF E318K variant associated with significantly increased melanoma risk and high nevus burden Specific gene variant linked to higher risk of multiple melanomas
This systematic review and meta-analysis of 8,606 melanoma patients and 17,953 controls identifies the MITF E318K variant as a moderate-pene…
A specific genetic variant called MITF E318K is linked to a significantly higher risk of developing multiple primary melanomas.
Sep 20, 2026
Sutureless renorrhaphy is noninferior to conventional renorrhaphy for trifecta achievement in robot-assisted partial nephrectomy
Oncology Meta-analysis
Sutureless renorrhaphy is noninferior to conventional renorrhaphy for trifecta achievement in robot-assisted partial nephrectomy Sutureless Technique Shows No Difference in Renal Cancer Surgery
This meta-analysis of 787 patients evaluated sutureless renorrhaphy versus conventional renorrhaphy in robot-assisted off-clamp partial neph…
A sutureless technique for closing the kidney during surgery shows similar results to traditional methods for patients with renal cancer.
Sep 9, 2026
PFOA exposure linked to modest kidney and breast cancer risk in meta-analysis
Oncology Meta-analysis
PFOA exposure linked to modest kidney and breast cancer risk in meta-analysis PFOA exposure tied to higher kidney and breast cancer risk
This meta-analysis of 34 datasets found that perfluorooctanoic acid (PFOA) exposure is associated with a modest increase in kidney cancer ri…
A new analysis links PFOA, a common chemical, to a modest rise in kidney and breast cancer risk. Liver and thyroid cancers showed no clear l…
Aug 2, 2026
Retroperitoneal approach in single-port robot-assisted partial nephrectomy may reduce blood loss and hospital stay
Oncology Meta-analysis
Retroperitoneal approach in single-port robot-assisted partial nephrectomy may reduce blood loss and hospital stay Retroperitoneal approach may offer benefits for kidney cancer surgery
This meta-analysis of 384 patients compares transperitoneal and retroperitoneal approaches for single-port robot-assisted partial nephrectom…
A new look at surgical methods suggests the retroperitoneal approach may reduce blood loss and hospital stays for patients with renal cancer…
Jul 21, 2026
Narrative review of lung, breast, liver, and kidney cancer evidence
Urology Meta-analysis
Narrative review of lung, breast, liver, and kidney cancer evidence New Cancer Tests Could Spot Tumors Years Earlier Than Before
This narrative review synthesizes published English-language evidence on lung, breast, liver, and kidney cancers. The authors note the scope…
A new wave of cancer biomarker tests can spot lung, breast, liver, and kidney tumors years earlier, opening the door to faster treatment and…
Frontiers May 9, 2026
Meta-analysis shows ERAS care improves recovery and reduces complications in laparoscopic nephrectomy for renal cancer
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis shows ERAS care improves recovery and reduces complications in laparoscopic nephrectomy for renal cancer ERAS Care Helps Kidney Cancer Patients Heal Faster
This meta-analysis evaluated enhanced recovery after surgery (ERAS) versus traditional care in 2,361 patients undergoing laparoscopic radica…
Kidney cancer patients recovering from surgery heal faster with a special plan, eating and walking sooner while spending less time in the ho…
Frontiers Apr 10, 2026
Systematic review of 2025 RCTs identifies new standards of care across genitourinary cancers
Diabetes & Endocrinology Meta-analysis
Systematic review of 2025 RCTs identifies new standards of care across genitourinary cancers New standards of care established for bladder, kidney, prostate, testicular, and penile cancers in 2025
A systematic review and meta-analysis of 40 phase II/III RCTs in patients with bladder, kidney, prostate, testicular, and penile cancers fou…
New 2025 standards of care for bladder, kidney, prostate, testicular, and penile cancers now emphasize biomarker-driven strategies and immun…
Frontiers Apr 9, 2026