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N/A N=50 Randomized Prevention

The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients

Hypoxia

Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Oct 2019
Primary outcome: Primary: PaO2(Partial Pressure of Oxygen in Arterial Blood) — 178.71; 198.04; 185.25; 202.54 mmHg

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
IE ratio 1:1 (Device); IE ratio 1:2 (Device)
Age
Adult, Older Adult · 20+ yrs
Sex
All
Sponsor
Gachon University Gil Medical Center
Primary completion
Apr 2019

Outcome Measures

OutcomeResultp-value
PRIMARY
PaO2(Partial Pressure of Oxygen in Arterial Blood)
178.71; 198.04; 185.25; 202.54

Summary

The area of aesthesia-induced atelectasis is much larger in the obese compared with the non-obese, but there may also be more airway closure and impaired matching of ventilation and lung blood flow. When an anesthetized patient is turned to the prone position, dynamic compliance (Cdyn) decreases and peak airway pressure increases unless the abdomen hangs freely to prevent the abdominal viscera from compromising the diaphragm movement. Although the Wilson frame is designed to allow the abdomen to hang, it partially compresses the anterior abdominal wall and therefore does not allow the abdomen to hang completely, especially in obese patients. This in turn increases peak airway pressure and decreases Cdyn, oxygenation. This study aimed to investigate the effects of a prolonged I:E ratio (i.e., 1:1) compared with the conventional I:E ratio of 1:2 on respiratory mechanics and hemodynamics during spine surgery in the prone position in obese patients. We hypothesized that, compared with an I:E ratio of 1:2, a ratio of 1:1 improve oxygenation without hemodynamic instability .

Eligibility Criteria

Inclusion Criteria

  • ASA I-II adult patients scheduled for spine surgery under general anesthesia.
  • patient age : greater than 20 years and less than 65years
  • Body Mass Index(BMI) >25 kg/m2

Exclusion Criteria

  • Patients who have severe pulmonary disease:

history of chronic obstructive pulmonary disease (COPD), asthma, or pneumothorax. Patients with haemodynamic instability, hypovolaemia, bronchopleural fistula, history of cardiopulmonary disease, or previous lung surgery are excluded.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02961920). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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