Phase 4
Completed N=198
Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality
Source: ClinicalTrials.gov NCT02961946 ↗Enrolled (actual)
198
Serious AEs
0.0%
Results posted
Sep 2019
Primary outcomePrimary: Coronary Artery Diameter Change — 1.14; 1.13; 1.15 Fold change
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
To evaluate image quality of coronary CT angiography (cCTA) after sublingual and transdermal administration of Nitroglycerin. Aim of this prospective research study is to investigate equivalence on image quality after sublingual or transdermal Nitroglycerin administration (H0).
Furthermore, the feasibility of transdermal Nitroglycerin administration will be evaluated.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Coronary Artery Diameter Change |
1.14; 1.13; 1.15 | — |
Eligibility Criteria
Inclusion Criteria
- Scheduled cCTA with contrast.
- Able to comprehend and sign the consent form.
Exclusion Criteria
- Known hypersensitivity to glyceryl trinitrate, and related organic nitrates.
- Acute circulatory failure associated with marked hypotension (shock).
- Conditions associated with elevated intracranial pressure, cerebral haemorrhage and head trauma.
- Closed-angle glaucoma.
- Phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil (Viagra®), tadalafil (Cialis), or vardenafil (Levitra) within the last 24 hours
- Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
- Critical aortic stenosis
- Systolic blood pressure < 90 mmHg
- Pregnant or lactating female; premenopausal women with a positive urine pregnancy test.
- Age under 18
- Unwilling or unable to inform consent.
Data sourced from ClinicalTrials.gov (NCT02961946). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.