Phase 4
Completed N=154
IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
Pain, Postoperative · Opioid Use Disorder
Source: ClinicalTrials.gov NCT03020966 ↗
Enrolled (actual)
154
Serious AEs
0.0%
Results posted
Aug 2021
Primary outcomePrimary: Pain With Physical Therapy on Post-operative Day 1 — 3.6; 3.9 score on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of this study is to determine how well two different methods of administrating Tylenol reduce pain and improve patient satisfaction after total hip replacement (THR) surgery. The methods of administration are orally, via a pill that is to be swallowed, and intravenously. Our aim is to determine whether oral or intravenous administration of Tylenol will reduce opioid consumption and opioid-related side effects after THR.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain With Physical Therapy on Post-operative Day 1 |
3.6; 3.9 | — |
| PRIMARY Opioid Use |
108; 121 | — |
| PRIMARY Opioid Side Effects |
0.4; 0.3 | — |
Eligibility Criteria
Inclusion criteria
- Adult
- Scheduled for an elective primary THA with a participating surgeon,
- Planned for Combined Spinal Epidural anesthesia (CSE) and Patient Controlled Epidural Analgesia (PCEA)
- English-speaking
- Patients that did not receive pre-operative opioids
Exclusion criteria
- Hepatic or renal insufficiency, as defined by abnormal readings on liver and kidney functioning tests.
- Hypersensitivity or contraindication to protocol medication
- Contraindication for CSE and PCEA
- Incapable to provide consent/answer questions in English
- Revision or urgent surgery
- Receiving Periarticular Injections
- History of opioid use
- Patients on disability or worker's compensation
Data sourced from ClinicalTrials.gov (NCT03020966). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.