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Home › Conditions › Opioid Use Disorder

Opioid Use Disorder

Subtypes of Opioid Use Disorder

Opioid Overdose 8 Opioid dependence 2 Opioid Addiction 1 Prescription Opioid Misuse 0

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Opioid Use Disorder

202 trials tracked for Opioid Use Disorder: 45 in phase 3 or 4 and 23 with published results. The most-cited published study has 167 citations.

202Trials tracked
45Phase 3 & 4
0Recruiting
23With published results
Phase distribution
Phase 4 26 Phase 3 19 Phase 2 19 Phase 1 18 Other / NA 120
  1. Phase 3 Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain Completed · 167 cited
  2. Phase 3 Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder Completed · 112 cited
  3. Phase 3 Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study Completed · 59 cited
  4. Phase 3 Does a Non-Opioid Multimodal Pain (NOMO) Protocol Decrease Narcotic Use Completed · 50 cited
  5. Phase 3 Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension) Completed · 48 cited
  6. Phase 4 Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment Completed · 47 cited
Show 44 more trials
  1. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 27 cited
  2. Phase 4 Pain Control Following Sinus Surgery Completed · 20 cited
  3. Phase 4 SUBLOCADE Rapid Initiation Study Completed · 16 cited
  4. Phase 3 Safety and Tolerability Study of Depot Buprenorphine in Treatment Seeking Subjects With Opioid Use Disorder Completed · 13 cited
  5. Phase 3 Open-Label Treatment Extension Study Completed · 13 cited
  6. Phase 3 Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up Completed · 13 cited
  7. Phase 4 Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control Completed · 11 cited
  8. Phase 3 Opioid Prescription After Cesarean Trial Completed · 11 cited
  9. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  10. Phase 3 Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL Completed · 8 cited
  11. Phase 4 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery Completed · 6 cited
  12. Phase 4 Evaluation of Buprenorphine Extended-Release Subcutaneous Injection at Alternative Injection Locations Completed · 6 cited
  13. Phase 4 The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery Completed · 6 cited
  14. Phase 4 The Impact of Perioperative Ketamine Infusion on Surgical Recovery Completed · 6 cited
  15. Phase 4 Prevention of Persistent Opioid Use in Mothers Completed · 5 cited
  16. Phase 4 Ketamine for Acute Pain Management After Trauma Completed · 5 cited
  17. Phase 4 Dronabinol in Total Knee Arthroplasty (TKA) Completed
  18. Phase 4 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section Completed
  19. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  20. Phase 4 Gabapentin Regimens and Their Effects on Opioid Consumption Completed
  21. Phase 4 IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty Completed
  22. Phase 4 Improving Post-Operative Pain and Recovery in Gynecologic Surgery Completed
  23. Phase 4 Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty Completed
  24. Phase 4 Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery Completed
  25. Phase 4 Rapid Initiation of Drug Treatment Engagement Completed
  26. Phase 4 Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection Completed
  27. Phase 4 Buprenorphine Loading in the Emergency Department Completed
  28. Phase 4 Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery Completed
  29. Phase 4 The Impact of Sublingual Sufentanil on Postoperative Pain and Analgesic Requirements in Spine Surgery Patients Completed
  30. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  31. Phase 4 Cannabidiol for Bilateral Total Knee Arthroplasty Completed
  32. Phase 3 Lorcaserin in Combination With XR-Naltrexone for Relapse Prevention in Opioid Use Disorder Completed
  33. Phase 3 Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery Completed
  34. Phase 3 Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial Completed
  35. Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Completed
  36. Phase 3 Exparel Use in Adductor Canal Block After Total Knee Arthroplasty Completed
  37. Phase 3 A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders Completed
  38. Phase 3 Lidocaine Patches After Cesarean Section Completed
  39. Phase 3 Perioperative Pregabalin in Ureteroscopy Completed
  40. Phase 2 Impact of Lofexidine on Stress, Craving and Opioid Use Completed
  41. Phase 2 Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections Completed
  42. Phase 2 A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists. Completed
  43. Phase 2 Enhancing Medication-based Analgesia in Humans- STUDY 2 Completed
  44. Phase 2 Remote Observed Dosing of Suboxone to Improve Clinical Practice Completed

Showing the 50 most-cited and recently-updated of 202 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
19 genome-wide significant loci identify genetic architecture and high correlations with other substance use disorders
Genetics & Precision Medicine Meta-analysis
19 genome-wide significant loci identify genetic architecture and high correlations with other substance use disorders Genes linked to stimulant addiction found in largest study yet
This meta-analysis of 709,369 individuals identifies 19 genome-wide significant loci associated with Stimulant Use Disorder. The study also …
Scientists found 19 genetic regions tied to stimulant addiction, including one linked to obesity. The study of over 700,000 people also show…
medRxiv Jun 11, 2026
High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings
Anesthesiology & Pain Medicine RCT
High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings New plan to test high-dose buprenorphine for opioid use disorder
This randomized clinical trial protocol describes a plan to evaluate high-dose buprenorphine induction for patients with moderate-to-severe …
A new clinical trial plans to see if higher doses of buprenorphine can help more people with opioid use disorder start treatment in the emer…
Jun 9, 2026
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
Infectious Disease RCT
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
May 1, 2026
Protocol for Systematic Review and Meta-Analysis of Dopaminergic Measures in Opioid Use Disorder
Psychiatry Meta-analysis
Protocol for Systematic Review and Meta-Analysis of Dopaminergic Measures in Opioid Use Disorder Opioid addiction changes brain chemistry in lasting ways
This publication outlines a protocol for a systematic review and meta-analysis investigating dopaminergic measures in adults with opioid use…
People with opioid addiction have clear changes in brain chemistry that may explain why cravings persist, even after stopping use, and could…
Frontiers May 1, 2026
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women
Anesthesiology & Pain Medicine Meta-analysis
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women Buprenorphine-based therapies reduce neonatal abstinence syndrome risk compared to methadone in pregnant women
This systematic review and meta-analysis evaluated buprenorphine-based therapies and methadone in pregnant opioid-dependent women.
A large review of 5,524 pregnant women found babies exposed to buprenorphine had lower rates of withdrawal symptoms and needed less medicati…
May 1, 2026
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients
Psychiatry Cohort
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients Combining buprenorphine and therapy boosts remission rates for opioid dependence
This retrospective cohort study analyzed 18,047 adults aged 18–45 with opioid dependence across 112 U.S.
In a large study, pairing buprenorphine with psychotherapy showed the strongest link to remission from opioid use disorder compared to no tr…
Frontiers Apr 28, 2026
Peer navigators provide direct, informational, and facilitation support for OUD during community re-entry
Anesthesiology & Pain Medicine RCT
Peer navigators provide direct, informational, and facilitation support for OUD during community re-entry What kind of help do people need most when leaving jail with opioid addiction?
A Connecticut RCT sub-study of 108 criminal legal-involved adults with OUD characterized peer navigator support during community re-entry.
When leaving jail, opioid recovery hinges on practical help like rides to appointments and paperwork support, not just medical advice.
Apr 8, 2026
Pilot study examines salivary adiponectin receptor expression in opioid-exposed neonates
Pediatrics Cohort
Pilot study examines salivary adiponectin receptor expression in opioid-exposed neonates How does a mother's opioid use affect her baby's growth signals?
This observational pilot cohort compared salivary adiponectin receptor 1 expression and growth measurements in neonates born at ≥34 weeks' g…
Doctors are investigating how a mother's opioid use during pregnancy might change a newborn's growth signals and body fat levels.
Frontiers Apr 7, 2026
Naloxone prescriptions from US retail pharmacies increased substantially from 2012 to 2018
Infectious Disease
Naloxone prescriptions from US retail pharmacies increased substantially from 2012 to 2018 Did naloxone access improve? Pharmacy prescriptions more than doubled in one year
An observational report of naloxone dispensing trends in US retail pharmacies found the number of prescriptions increased substantially from…
Naloxone prescriptions at U.S. retail pharmacies more than doubled from 2017 to 2018, showing a major jump in access to this life-saving ove…
CDC Apr 6, 2026
Report estimates state-level economic costs of opioid use disorder and fatal overdose
Infectious Disease
Report estimates state-level economic costs of opioid use disorder and fatal overdose Report estimates state-level economic costs of opioid use disorder and overdose
A report estimated state-level economic costs of opioid use disorder and fatal opioid overdose in the United States.
A new report estimates the economic costs of opioid use disorder and fatal overdoses for every state in the United States in 2017.
CDC Apr 6, 2026
Report describes overdose education and naloxone distribution programs in U.S. syringe service programs
Infectious Disease
Report describes overdose education and naloxone distribution programs in U.S. syringe service programs How do syringe programs teach people to stop overdoses?
A report describes overdose education and naloxone distribution (OEND) programs within syringe service programs in the United States.
A new report looks at how syringe service programs across the U.S.
CDC Apr 6, 2026
In adult ED encounters, clinician engagement with EHR-based SDOH data was rare but higher in opioid use disorder cases
Emergency Medicine
In adult ED encounters, clinician engagement with EHR-based SDOH data was rare but higher in opioid use disorder cases Did reviewing social data in the ER actually change how doctors treated opioid use disorder patients?
This cross-sectional study of 17,103 adult emergency department encounters examined clinician engagement with electronic health record-based…
Doctors reviewed social data more often for opioid use disorder patients, yet this action did not increase medication treatments or fix raci…
medRxiv Apr 6, 2026

Questions about Opioid Use Disorder

Are there differences in newborn growth measurements for babies exposed to opioids in the womb?

Yes, babies exposed to opioids in the womb tend to have lower birth weight and smaller head circumference, with differences depending on the specific medication used.

Full answer →

All Opioid Use Disorder Articles