N/A
Completed N=42
Patient Centered-Rehabilitation ver111090.1
Cognitive Change
Source: ClinicalTrials.gov NCT03034954 ↗
Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Aug 2018
Primary outcomePrimary: Object Location Touchscreen Task (Version C) Free Recall Total Error — 121.498; 99.77 centimeters — p=.300
Summary
As we age, a number of factors can reduce our cognitive (or thinking) abilities. This study will evaluate whether transcranial electrical stimulation (TES), which uses small amounts of electricity to modulate brain functioning, can improve cognitive abilities. Here, the effects of TES on working memory, learning, and memory, will be evaluated in a group of healthy older adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Object Location Touchscreen Task (Version C) Free Recall Total Error |
121.498; 99.77 | .300 |
| PRIMARY Object Location Touchscreen Task (Version C) Free Recall Average Error |
8.099; 6.652 | — |
| PRIMARY Object Location Touchscreen Task (Version C) Free Recall Average Time to Respond |
3419.878; 3029.648 | .044 sig |
| PRIMARY Object Location Touchscreen Task (Version C) Cued Recall Total Error |
66.806; 43.775 | — |
| PRIMARY Object Location Touchscreen Task (Version C) Cued Recall Average Error |
4.453; 2.919 | — |
| PRIMARY Object Location Touchscreen Task (Version C) Cued Recall Average Time to Respond |
3991.659; 2666.858 | .15 |
| PRIMARY Object Location Touchscreen Task (Version C) Recognition Total Correct |
12.79; 13.45 | — |
| PRIMARY Object Location Touchscreen Task (Version C) Recognition Average Time to Respond |
2804.459; 1903.39 | .3 |
| PRIMARY Performance (d') on a Simple Attention (0-back) Test |
4.26; 4.25 | — |
| PRIMARY Performance (d') on a Working Memory (2-back) Test |
3.05; 2.94 | — |
| PRIMARY Performance (d') on a Working Memory (Semantic 2-back) Test |
1.518; 1.69 | — |
| PRIMARY Calculated Working Memory Performance Accounting for Simple Attention (2-back d' Minus 0-back d') |
-1.130; -1.31 | — |
| PRIMARY Calculated Working Memory Performance Accounting for Simple Attention (Semantic 2-back d' Minus 0-back d') |
-2.69; -2.56 | .450 |
| SECONDARY Blinding in Total Sample |
9; 6; 9; 8; 1; 7 | .078 |
| SECONDARY Frequency of Endorsement (%) for Headache Item in Active and Sham Participants Undergoing HD-tDCS Session |
19; 18; 0; 3; 0; 0 | .233 |
| SECONDARY Frequency of Endorsement (%) for Neck Pain Item in Active and Sham Participants Undergoing HD-tDCS Session |
19; 21; 0; 0; 0; 0 | — |
| SECONDARY Frequency of Endorsement (%) for Scalp Pain Item in Active and Sham Participants Undergoing HD-tDCS Session |
16; 20; 1; 0; 1; 1 | .600 |
| SECONDARY Frequency of Endorsement (%) for Tingling Item in Active and Sham Participants Undergoing HD-tDCS Session |
6; 7; 12; 11; 1; 2 | .999 |
| SECONDARY Frequency of Endorsement (%) for Itching Item in Active and Sham Participants Undergoing HD-tDCS Session |
16; 14; 3; 7; 0; 0 | .281 |
| SECONDARY Frequency of Endorsement (%) for Burning Item in Active and Sham Participants Undergoing HD-tDCS Session |
9; 7; 10; 8; 0; 5 | .082 |
| SECONDARY Frequency of Endorsement (%) for Skin Redness Item in Active and Sham Participants Undergoing HD-tDCS Session |
19; 19; 0; 2; 0; 0 | .490 |
| SECONDARY Frequency of Endorsement (%) for Sleepiness Item in Active and Sham Participants Undergoing HD-tDCS Session |
19; 18; 0; 2; 0; 1 | .488 |
| SECONDARY Frequency of Endorsement (%) for Concentration Changes Item in Active and Sham Participants Undergoing HD-tDCS Session |
17; 21; 2; 0; 0; 0 | .219 |
| SECONDARY Frequency of Endorsement (%) for Mood Changes Item in Active and Sham Participants Undergoing HD-tDCS Session |
19; 21; 0; 0; 0; 0 | — |
Eligibility Criteria
Inclusion Criteria
- Individuals with intact cognitive functioning.
- Participants will be age 50 or older.
Exclusion Criteria
- Individuals with a documented history of cognitive impairment.
- A history of serious mental illness (e.g., bipolar disorder, schizophrenia, axis 2 disorders)
- Sensory or motor impairments that limit the ability to take part in the study
- A significant history or current use of alcohol or drug abuse/dependence
- Those who are currently pregnant (if there is a question of pregnancy, pregnancy tests will be available for participants at no charge)
- Participants with an Mini Mental State Examination score <24 at screening.
Data sourced from ClinicalTrials.gov (NCT03034954). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.