N/A N=8 Randomized Basic Science

Low Intensity Blood Flow Restriction Training Study

Muscle Mass

Bottom Line

View on ClinicalTrials.gov: NCT03055260 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2020

Primary outcome: Primary: One Repetition Maximum — 302.9 pounds

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Blood flow restriction cuff (Device); Blood Flow restriction Cuff-Placebo (Device)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of Minnesota
Primary completion: Dec 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY One Repetition Maximum	302.9	—
SECONDARY Quadriceps Muscle Thickness	45	—

Summary

The particpant will complete baseline testing by measuring subjects' quadriceps muscle thickness (cm) via ultrasound technology, as well as have them complete a one repetition maximum (1RM) test on the leg press machine and an isometric knee extension using a dynamometer - strength measures will be calculated for both right and left legs. After baseline testing, subjects will complete 6 weeks of the testing protocol that will consist of leg press exercises at 30% of their 1RM. Subjects will be randomized to either wear a cuff that partially restricts blood flow to the limb (Study Group), or to wear a cuff that does not restrict blood flow (Control Group). Exercises will be completed 2x/week and will take approximately 10 total minutes (5 for warm up, 5 for testing protocol) per session. After 6 weeks, muscle thickness, leg press 1RM, and quadriceps extension strength will be re-tested and compared to the initial measurements.

Eligibility Criteria

Inclusion Criteria

Age 18-49

Exclusion Criteria

Pregnant
Hypertensive
Recent back or lower extremity injury
History of blood clotting
Varicose veins
Adults lacking the capacity to consent for themselves

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03055260). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.