Phase 3 Completed N=75 Randomized Triple-blind Prevention

Comparing Bupivacaine, Lidocaine, and a Combination of Bupivacaine and Lidocaine for Labor Epidural Activation

Postoperative Pain

Source: ClinicalTrials.gov NCT03103100 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2020

Primary outcomePrimary: Time to Achieve an Adequate Epidural Level for Labor Analgesia — 7.0; 11.0; 8.5 minutes

◆ Published Evidence

No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

This study will compare and determine the most ideal local anesthetic (LA) solution to activate a labor epidural: lidocaine, bupivacaine, or a combination of bupivacaine plus lidocaine.

Outcome Measures

Outcome	Result	p-value
PRIMARY Time to Achieve an Adequate Epidural Level for Labor Analgesia	7.0; 11.0; 8.5	—
SECONDARY Number of Patients Who Achieve Adequate Analgesia	23; 25; 23	—
SECONDARY Degree of Motor Block	2.0; 1.7; 1.9	—
SECONDARY Number of Patients Who Experienced of Maternal Hypotension	4; 0; 0	—

Eligibility Criteria

Inclusion Criteria

Pregnant patients over the age of 19 who are scheduled for an induction of labor and request an epidural are eligible for the study

Exclusion Criteria

age <19
allergy to the drug or drug class
preexisting neuropathy
history of back pain prior to pregnancy or history of back surgery
history of chronic opioid use
history of hypertension or hypertensive disorders of pregnancy
congenital or acquired cardiac disease
contraindication to epidural placement (patient refusal, severe coagulopathy, infection at site of epidural needle insertion, severe hypovolemia)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03103100). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.