N/A
Completed N=20
Combining tDCS and Neurorehabilitation to Treat Age-related Deficits of Mobility and Cognition: UPfront Walking Study
Mobility Limitation · Mild Cognitive Impairment
Source: ClinicalTrials.gov NCT03122236 ↗
Enrolled (actual)
20
Serious AEs
5.0%
Results posted
Jun 2024
Primary outcomePrimary: Mobility: Figure-of-eight Walking Test (Figure-8 Walk Test) — 10.57; 9.58; 11.00 seconds
Summary
Loss of mobility and cognitive ability are serious conditions that threaten the independence of older adults. The objective of this study is to initiate a line of research to develop a novel therapeutic intervention to enhance both mobility and cognition via neuroplasticity of frontal/executive circuits.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mobility: Figure-of-eight Walking Test (Figure-8 Walk Test) |
10.57; 9.58; 11.00 | — |
| SECONDARY Cognitive Composite Executive Score on EXAMINER Battery |
-0.19; 0.29; 0.03 | — |
Eligibility Criteria
Inclusion criteria
- preferred 10m walking speed 180 mmHg and/or diastolic > 100 mmHg)
- low vision that cannot be corrected by wearing glasses. Low visual will be operationally defined as visual acuity less than 20/70 on a standard eye chart, or difficulty performing complex walking tasks due to visual conditions affecting accurate navigation around and over obstacles (self-reported or observed by examiner).
- illiterate, due to the likelihood of difficulties performing some of the cognitive tasks
- non-English speaking, due to the likelihood of difficulties following instructions during therapy and during assessments
- use of medications that are know to modify tDCS effectiveness including those with anticholinergic, GABAergic, or glutamatergic properties, or sodium channel blockers
- clinical judgment of investigative team
Data sourced from ClinicalTrials.gov (NCT03122236). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.