Phase 3
Completed N=101
Preoperative Acetaminophen and Carbohydrate Loading
Source: ClinicalTrials.gov NCT03131713 ↗Enrolled (actual)
101
Serious AEs
0.0%
Results posted
Oct 2019
Primary outcomePrimary: Maximum Pain Score — 2.8; 1.2 units on a pain scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The study's goal is to assess impact of preoperative acetaminophen and oral carbohydrate drinks on pain and functional status experienced by patients undergoing Mohs micrographic surgery for non-melanoma skin cancers. Patients are randomly assigned to receive standard of care or preoperative acetaminophen 1000 mg and Gatorade sports drinks 2 packets before surgery. Patients are then asked to rate their level of pain, anxiety, thirst, hunger, fatigue on a scale of 0-100 on day of surgery before surgery has started, after clearance of skin cancer, and at the end of the visit. Patients are contacted by phone 48 hours after their surgery to assess their maximum level of post-operative pain (rated from 0-100), usage of over the counter or prescribed pain medications, and presence of complications e.g. bleeding, infection, dehiscence. Differences in perioperative functional status and pain medication usage are compared between patients in control and intervention groups.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximum Pain Score |
2.8; 1.2 | — |
| SECONDARY Thirst |
9.4; 10.5 | — |
| SECONDARY Hunger |
19.9; 17.9 | — |
| SECONDARY Anxiety |
7.6; 2.2 | — |
| SECONDARY Fatigue |
12; 10.7 | — |
| SECONDARY Number of Participants Using Post-operative Analgesic |
27; 34 | — |
| SECONDARY Maximum Post-op Pain Score |
14; 13.6 | — |
Eligibility Criteria
Inclusion Criteria
- Adult patients undergoing Mohs micrographic surgery for non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma)
Exclusion Criteria
- history of liver transplant, hepatitis, or cirrhosis, those required to be NPO for subsequent closure by other surgical specialties, or those with known allergy to acetaminophen
Data sourced from ClinicalTrials.gov (NCT03131713). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.