Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
Actinic Keratosis Linked to Higher Risk of Melanoma
This meta-analysis of genome-wide association studies evaluates causal relationships between 11 modifiable risk factors and skin cancers. Th…
New research identifies a link between actinic keratosis and melanoma risk while highlighting potential new targets for skin cancer treatmen…
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
Sugar sweetened drinks may increase risk of several cancer types
This meta-analysis of 51 cohort studies evaluates the link between sugar sweetened beverages (SSBs), artificially sweetened beverages (ASBs)…
New research suggests a link between sugar-sweetened beverages and an increased risk of certain cancers, including pancreatic and colorectal…
Fianlimab plus cemiplimab showed objective response rates of 20% to 33% in advanced solid tumors during a Phase 1 study.
Early trial shows new cancer drug combo helps some patients with advanced disease
This Phase 1, first-in-human dose-expansion study evaluated fianlimab 1600 mg plus cemiplimab 350 mg in patients with advanced non-small cel…
A new drug combination helped some patients with advanced lung, kidney, head and neck, or skin cancer shrink their tumors in early testing.
Meta-analysis of sirolimus for cutaneous squamous cell carcinoma in kidney transplant recipients
Sirolimus lowers skin cancer risk in kidney transplant patients
This meta-analysis of four randomized trials in kidney transplant recipients with prior cutaneous squamous cell carcinoma found that switchi…
A review of studies shows switching to sirolimus can cut skin cancer rates, but it may cause more side effects.
5-Fluorouracil and MAL-PDT vs Surgery for Bowen's Disease: 4-Year Outcomes
Surgery kept skin cancer away better than two light-based treatments in this trial
This multicenter RCT compared 5-fluorouracil, methylaminolevulinate photodynamic therapy (MAL-PDT), and surgical excision (SE) in 250 patien…
Surgery offered the highest chance of staying cancer-free for four years, while light-based treatments showed lower success rates in this st…
Post-Mohs reconstruction for periocular malignancies shows low complication rates in retrospective review
New data shows how eyelid surgery outcomes depend on defect size
This retrospective cohort review of 194 adults at a tertiary referral center assessed outcomes after post-Mohs reconstruction for periocular…
Most eyelid cancer surgeries heal well, but wound size and past health history strongly influence final results for older adults.
Meta-analysis identifies germline susceptibility loci for rare cancers including MDS and GIST
Genes linked to rare cancers found in large study of over 480,000 people
This meta-analysis of observational cohorts from over 480,000 individuals identified novel germline susceptibility loci for rare cancers.
A huge study of over 480,000 people found new genes that raise the risk of several rare cancers, offering clues for families and doctors.
Research across Cancer
Related studies from across the Cancer family.
AI-assisted clinicians achieve 1.000 sensitivity in melanoma diagnosis but autonomous AI lacks clear clinical advantage
Artificial Intelligence Shows Mixed Results in Detecting Melanoma
This meta-analysis of 17 diagnostic arms from 10 studies evaluates artificial intelligence for dermoscopic image analysis in melanoma detect…
New research shows that while AI can help identify skin cancer, it does not yet outperform traditional methods used by doctors.
Opsin 3 serves as a potential therapeutic target for melanoma and inflammatory skin diseases
Opsin 3 May Offer New Path for Skin Disease Treatment
This narrative review explores the role of Opsin 3 (OPN3) in skin pathophysiology, including its involvement in UV damage, melanoma developm…
A protein called Opsin 3 may play a key role in how skin cells respond to UV damage, aging, and inflammation.
AI diagnostic tools show high accuracy but limited real-world validation in systematic review
Artificial intelligence shows high accuracy in detecting various medical conditions
This systematic review of 24 studies synthesizes evidence on AI and deep learning for disease detection across multiple imaging modalities. …
New analysis of 24 studies shows AI tools can reach over 90% accuracy in spotting everything from lung cancer to skin disorders.
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
IO102-IO103 plus pembrolizumab improves progression-free survival in advanced melanoma patients
Trial shows combination therapy may extend time before melanoma progresses
This Phase III randomized controlled trial of 407 patients with untreated advanced melanoma evaluated IO102-IO103 (85 μg) combined with pemb…
A new clinical trial suggests that combining two specific drugs may help patients with advanced melanoma stay stable for longer periods.
Motivation-informed digital reminders do not improve task completion compared to standard wording in melanoma trial
Standard Digital Reminders Work Well for Melanoma Monitoring Tasks
This randomized study within a trial (SWAT) of 260 participants in a melanoma surveillance program found that motivation-informed digital re…
New research shows that standard digital reminders are just as effective as motivation-based ones for helping patients complete melanoma mon…
Narrowband UVB remains first-line phototherapy for vitiligo, with JAK inhibitors emerging as adjuncts
New light therapies and skin grafts offer hope for vitiligo patients
This narrative review synthesizes current evidence on phototherapy for vitiligo, highlighting narrowband UVB as the mainstay. Excimer lasers…
A review of treatments for vitiligo highlights options like narrowband ultraviolet B light, excimer therapy, and cellular grafting that may …
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
Fertility Drugs Linked to Slight Rise in Melanoma Risk
This systematic review and meta-analysis evaluated melanoma incidence in infertile women exposed to fertility treatments compared to untreat…
A large review finds fertility drugs may raise melanoma risk slightly, but the increase is small and more research is needed.
TIL therapy and engineered viral vector immunotherapies show pooled ORR of 37.8% in advanced melanoma
First new analysis in years shows TIL therapy response rates for advanced melanoma
This Bayesian meta-analysis synthesizes data from 13 eligible studies on TIL therapy and engineered viral vector immunotherapies for advance…
A Bayesian meta-analysis of 13 studies finds TIL therapy yields a 49% response rate in advanced melanoma, with moderate certainty for respon…
Systematic Review: Intercellular Mitochondrial Transfer in Melanoma Progression and Resistance
Mitochondrial Transfer Fuels Melanoma Resistance and Spread
This systematic review examines the role of intercellular mitochondrial transfer in melanoma. The authors find that this process contributes…
A systematic review reveals that intercellular mitochondrial transfer helps melanoma resist therapies and spread, but may also suppress tumo…
Meta-analysis finds germline LTS and somatic TERT variants are mutually exclusive in thyroid cancer and melanoma
Two different cancer drivers do not appear together in these tumors
This meta-analysis of retrospective observational cohorts examined germline long-telomere syndrome variants and somatic TERT promoter altera…
A large review of nearly 2,000 adults with thyroid cancer or melanoma found that two specific genetic changes never occur in the same tumor.
Systematic review and meta-analysis of AI for melanoma risk assessment in pigmented skin lesions
AI plus doctors finds every skin cancer case in real-world settings
This systematic review and meta-analysis synthesized evidence from 17 diagnostic arms on AI, dermoscopy, and AI-assisted clinicians for mali…
When doctors used AI alongside standard skin checks, they caught every cancer case without missing any, showing a powerful new way to help p…