Artificial Intelligence Performance in Dermatoscopic Image Interpretation for Skin Cancer Diagnosis
AI Shows High Performance in Detecting Skin Cancer Images
A meta-analysis of 208 articles evaluates how AI compares to expert dermatoscopy in identifying melanoma and other common skin malignancies.
Artificial intelligence may improve the accuracy of diagnosing skin cancers like melanoma when analyzing specialized skin images.
Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
Mitophagy acts as a barrier to skin cancer immunotherapy
This narrative review explores how mitophagy functions as a barrier to immunotherapy in melanoma, cutaneous squamous cell carcinoma, and bas…
A cellular process called mitophagy may help skin cancers hide from the immune system, making it harder for certain treatments to work.
Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
Actinic Keratosis Linked to Higher Risk of Melanoma
This meta-analysis of genome-wide association studies evaluates causal relationships between 11 modifiable risk factors and skin cancers. Th…
New research identifies a link between actinic keratosis and melanoma risk while highlighting potential new targets for skin cancer treatmen…
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
Sugar sweetened drinks may increase risk of several cancer types
This meta-analysis of 51 cohort studies evaluates the link between sugar sweetened beverages (SSBs), artificially sweetened beverages (ASBs)…
New research suggests a link between sugar-sweetened beverages and an increased risk of certain cancers, including pancreatic and colorectal…
Fianlimab plus cemiplimab showed objective response rates of 20% to 33% in advanced solid tumors during a Phase 1 study.
Early trial shows new cancer drug combo helps some patients with advanced disease
This Phase 1, first-in-human dose-expansion study evaluated fianlimab 1600 mg plus cemiplimab 350 mg in patients with advanced non-small cel…
A new drug combination helped some patients with advanced lung, kidney, head and neck, or skin cancer shrink their tumors in early testing.
Meta-analysis of sirolimus for cutaneous squamous cell carcinoma in kidney transplant recipients
Sirolimus lowers skin cancer risk in kidney transplant patients
This meta-analysis of four randomized trials in kidney transplant recipients with prior cutaneous squamous cell carcinoma found that switchi…
A review of studies shows switching to sirolimus can cut skin cancer rates, but it may cause more side effects.
5-Fluorouracil and MAL-PDT vs Surgery for Bowen's Disease: 4-Year Outcomes
Surgery kept skin cancer away better than two light-based treatments in this trial
This multicenter RCT compared 5-fluorouracil, methylaminolevulinate photodynamic therapy (MAL-PDT), and surgical excision (SE) in 250 patien…
Surgery offered the highest chance of staying cancer-free for four years, while light-based treatments showed lower success rates in this st…
Post-Mohs reconstruction for periocular malignancies shows low complication rates in retrospective review
New data shows how eyelid surgery outcomes depend on defect size
This retrospective cohort review of 194 adults at a tertiary referral center assessed outcomes after post-Mohs reconstruction for periocular…
Most eyelid cancer surgeries heal well, but wound size and past health history strongly influence final results for older adults.
Meta-analysis identifies germline susceptibility loci for rare cancers including MDS and GIST
Genes linked to rare cancers found in large study of over 480,000 people
This meta-analysis of observational cohorts from over 480,000 individuals identified novel germline susceptibility loci for rare cancers.
A huge study of over 480,000 people found new genes that raise the risk of several rare cancers, offering clues for families and doctors.
Research across Cancer
Related studies from across the Cancer family.
Dual immune checkpoint inhibition provides durable intracranial progression-free survival in melanoma patients with brain metastases
Dual immune therapy shows promise for melanoma brain metastases
This meta-analysis of 3,518 patients with cutaneous or mucosal melanoma brain metastases indicates that dual immune checkpoint inhibition pr…
Combining two immune therapies may offer more durable results for patients with melanoma that has spread to the brain.
miR-155 overexpression is frequently associated with treatment resistance across 8 cancer types
miR-155 Expression Linked to Treatment Resistance in Various Cancers
This systematic review of 19 studies across 8 cancer types indicates that miR-155 overexpression is associated with treatment resistance in …
Research suggests that high levels of a specific molecule, miR-155, may be linked to how well certain cancers respond to treatment.
PD-1/PD-L1 inhibitors with SRS or FSRT achieve 87% one-year local control in brain metastases
Combining immunotherapy and radiation for brain metastases shows promise
This meta-analysis of 2587 patients with brain metastases evaluated the combination of PD-1/PD-L1 inhibitors with stereotactic radiosurgery …
A new analysis shows that combining specific immunotherapy drugs with radiation can help control brain tumors and manage side effects.
Genetic risk factors and a validated polygenic risk score identify melanoma risk loci
Genetic Risk Factors Linked to Melanoma Development Identified
This meta-analysis of 69,871 cases and 1,616,233 controls identifies 156 independent signals at 116 risk loci for cutaneous melanoma. The st…
Researchers identified over 150 genetic signals linked to melanoma, helping to better understand how genetics influence skin cancer risk.
CIC-Rearranged Intracranial Sarcoma: Local Control Achieved but Distant Spread Rapid Despite Multimodal Therapy
Rare brain tumor appears in patient with history of melanoma
This is a single-patient case report of a 36-year-old woman with a prior history of melanoma who developed an intracranial sarcoma. Gross to…
A 36-year-old woman with a history of melanoma developed a rare type of brain tumor called an intracranial sarcoma.
mRNA vaccines provide a clinically validated platform to induce durable anti-tumor immunity in solid tumors
mRNA Vaccines Show Potential for Treating Several Solid Tumors
This systematic review evaluates mRNA vaccines for melanoma, pancreatic cancer, and non-small cell lung cancer. The authors conclude that mR…
mRNA technology is being used to create cancer vaccines that may help patients with melanoma, pancreatic, and lung cancers by building lasti…
Approximately 40% to 55% of patients with advanced melanoma exhibit primary resistance to PD-1 monotherapy
PD-1 Inhibitors Show Varying Resistance Rates in Advanced Melanoma
This systematic review examines resistance mechanisms to PD-1 and PD-L1 inhibitors in patients with advanced melanoma. It identifies primary…
New research identifies specific rates of initial and acquired resistance to PD-1 inhibitors in patients with advanced melanoma.
MITF E318K variant associated with significantly increased melanoma risk and high nevus burden
Specific gene variant linked to higher risk of multiple melanomas
This systematic review and meta-analysis of 8,606 melanoma patients and 17,953 controls identifies the MITF E318K variant as a moderate-pene…
A specific genetic variant called MITF E318K is linked to a significantly higher risk of developing multiple primary melanomas.
Melanoma Immunoediting Review Maps Elimination, Equilibrium, Escape and Drivers of Immunotherapy Resistance
Immune System Changes Drive Melanoma Growth and Treatment Resistance
This systematic review synthesizes the tumor immunoediting framework in melanoma, describing three sequential phases (elimination, equilibri…
New research highlights how the immune system's failure to eliminate melanoma cells leads to tumor growth and resistance to current therapie…
Medicinal plant extracts and phytochemicals show potential as multitargeted candidates for metastatic melanoma
Plant extracts show promise for treating advanced melanoma skin cancer
This narrative review explores the potential of medicinal plant extracts and isolated phytochemicals as multitargeted therapeutic candidates…
Certain medicinal plants and their natural compounds may offer a new way to target multiple pathways in advanced melanoma.
Self-administered ivermectin and fenbendazole in a patient with metastatic melanoma showed mixed radiographic and ctDNA responses
One man with melanoma tries antiparasitic drugs for his cancer
This case report describes a 74-year-old man with metastatic melanoma who self-administered ivermectin and fenbendazole. The patient experie…
A man with advanced melanoma saw a temporary drop in cancer markers after taking ivermectin and fenbendazole, but the results were mixed.
Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma
Trial Shows Encorafenib and Binimetinib for Melanoma Patients
This trial evaluates the safety and efficacy of encorafenib and binimetinib in patients with resected stage IIB/IIC melanoma.
A clinical trial shows that a combination of encorafenib and binimetinib may improve recurrence-free survival for patients with specific mel…