N/A
N=77
Sex Differences, Cognitive Training & Emotion Processing
Alcohol Use Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03137654 ↗Enrolled (actual)
77
Serious AEs
0.0%
Results posted
May 2025
Primary outcome: Primary: Emotional Stroop: Change From Baseline in Reaction Time — 336; 162; 78.3 milliseconds — p=.0078
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Affective Training (Other); Neutral Training (Other)
- Age
- Adult, Older Adult · 25+ yrs
- Sex
- All
- Sponsor
- University of Florida
- Primary completion
- Feb 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Emotional Stroop: Change From Baseline in Reaction Time |
336; 162; 78.3 | .0078 sig |
| PRIMARY Trail-Making Task A: Change From Baseline in Task Completion Time |
— | — |
| PRIMARY Trail-Making Task B: Change From Baseline in Task Completion Time |
— | — |
| PRIMARY Digit Symbol Substitution: Change From Baseline in Translated Symbols |
— | — |
| PRIMARY Little Man Task: Change From Baseline in Response Accuracy. |
-.0045; .125; .0483 | 0.393 |
| PRIMARY Wisconsin Card Sorting Task: Change From Baseline in Response Accuracy |
— | — |
| PRIMARY Sternberg Working Memory Task: Change From Baseline in Response Accuracy |
.0021; 0.0298; 0.148 | .0344 sig |
| PRIMARY Stroop Color-Word Task: Change From Baseline in Response Time |
5; -11.5; 22 | .0344 sig |
| PRIMARY Visual-Perceptual Analysis Task: Change From Baseline in Response Time |
-1270; 121; -377 | 0.0365 sig |
| SECONDARY Timeline Follow-back |
.06; .131; .4 | .212 |
| SECONDARY Moos Health and Daily Living Scale |
1.33; .4; .25 | <.001 sig |
| SECONDARY Change in Profile of Mood States |
-12.7; 6.67; 1.25 | .445 |
| SECONDARY Mini Alcohol Craving Experience Questionnaire |
15.7; 10; 5.2 | .245 |
Summary
This pilot project addresses two understudied questions related to neurocognitive deficits observed in treatment-seeking alcoholics. First, whether cognitive training improves performance and outcomes in alcoholics, and whether men and women differ in their response to this training. The second is whether directed training using affective materials (e.g., emotional faces) is differentially effective compared to that using traditional (i.e., neutral) stimuli.
Eligibility Criteria
Inclusion Criteria
- Minimum of 10 years of education
- Subjects must have 20/40 or better corrected vision (determined by Snellen chart)
- have no significant hearing impairment as determined by self-report and audiometric testing
- must meet criteria for DSM-IV alcohol dependence using the computerized Diagnostic Interview Schedule - IV
- A craving index is also administered to allow discussion in terms of DSM 5 classification.
- Comorbid substance use including nicotine use is not exclusionary.
Exclusion Criteria
- May not have medical or psychiatric histories which would confound participation or data interpretation, e.g., epilepsy, stroke, untreated hypertension, psychotic disorders, anxiolytic medications.
- not be color blind (as determined by psuedoisochromatic plates)
- Endorsement of suicidal intent
Data sourced from ClinicalTrials.gov (NCT03137654). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.