N/A
Completed N=50
Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors
Source: ClinicalTrials.gov NCT03185546 ↗Enrolled (actual)
50
Serious AEs
1.3%
Results posted
May 2021
Primary outcomePrimary: Total Cigarettes Smoked Per Day — 21.6; 7.7; 18.4; 12.5 number of cigarettes
Summary
Project 2 will evaluate the impact of very low nicotine content cigarettes, e-cigarette nicotine content, and e-cigarette flavoring on cigarettes smoked per day, nicotine exposure, puff topography, discomfort/dysfunction, other health-related behaviors, nicotine/tobacco dependence, biomarkers of tobacco exposure, intention to quit, compensatory smoking, other tobacco use, cardiovascular function, and perceived risk. Project 2 will also evaluate differences between conditions in compliance with product use and the ability to abstain from cigarette smoking when provided a financial incentive for abstinence from combusted tobacco. This is not a treatment program for smoking.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Cigarettes Smoked Per Day |
21.6; 7.7; 18.4; 12.5; 34; 18.7 | — |
| SECONDARY Measure of Cigarette Exposure Using Expired Carbon Monoxide (CO) |
31; 7.2; 18; 12; 18.2; 21 | — |
| SECONDARY Number of Subjects With Smoke Free Days |
1; 1; 3; 3; 4; 3 | — |
Eligibility Criteria
Inclusion Criteria
- Smokers who have tried vaping multiple times.
- Generally good health.
Exclusion Criteria
- If female, currently pregnant, trying to become pregnant or breastfeeding.
- Planning to quit smoking.
Data sourced from ClinicalTrials.gov (NCT03185546). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.