N/A
N=15
Fatiguing Arm Exercise Following Stroke
Stroke
Bottom Line
View on ClinicalTrials.gov: NCT03194464 ↗Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Jun 2020
Primary outcome: Primary: Short Intracortical Inhibition (SICI) — 0.83; 1.14; 0.89; 0.88 SICI ratio — p=0.15
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- submaximal exercise (grip) (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- May 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Short Intracortical Inhibition (SICI) |
0.83; 1.14; 0.89; 0.88; 0.82; 0.87 | 0.15 |
| PRIMARY SICI Ratio |
0.89; 0.85; 0.93; 0.80; 0.78; 0.77 | .83 |
Summary
This study investigates the effects of sub-maximal exercise to task-failure (e.g., fatigue) with the less involved, or so-called non-paretic hand, in people who have experienced a stroke. In previous work the investigators found that non-paretic hand exercise to task-failure increased excitability of the motor cortex in the more involved hemisphere and produced behavioral improvements in the unexercised paretic hand. Importantly, the magnitude of increased brain excitability is greater than what has been observed following brain stimulation with either repetitive transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) and lasts longer. This approach could be implemented in the clinical setting and could be accessible to a greater number of people than brain stimulation. The investigators' goals in the current study are to: repeat previous findings in a different group of participants and investigate the neural mechanisms that produce brain and behavioral facilitation in order to inform development of this approach for clinical implementation.
Eligibility Criteria
Inclusion Criteria
- individuals at least 6 months post-stroke in the cortical or sub-cortical distribution with residual upper-extremity hemiparesis
- Non-Veteran Participants are eligible
Exclusion Criteria
- multiple strokes
- strokes in both hemispheres
- brainstem/medullary/cerebellar stroke
- seizure disorder
- metal implants in head or neck
- pacemaker or other implanted device
- inability to produce any measurable grip force
Data sourced from ClinicalTrials.gov (NCT03194464). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.