N/A
Completed N=95
Neuroplasticity in Parkinson´s Disease After Training
Parkinson's Disease · Physical Activity · Gait Disorders, Neurologic · Neural Degeneration
Source: ClinicalTrials.gov NCT03213873 ↗
Enrolled (actual)
95
Serious AEs
0.0%
Results posted
Mar 2025
Primary outcomePrimary: Mini-BESTest — 20.7; 21.0; 22.1; 21.8 score on a scale — p=0.57
Summary
This project aims to determine the effects of the HiBalance program on neuroplastic changes in people with mild to moderate Parkinson´s disease. The main hypothesis is that highly challenging exercise will lead to greater gait and balance ability, increased levels of physical activity and an improved health related quality of life. The investigators further hypothesize that neuroplasticity changes will be seen in corresponding areas of the brain, neuropsychological changes on cognitive test measures, and that exercise will inhibit the degeneration of dopaminergic neurons in the brain through the mediation of neurotrophic factors.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mini-BESTest |
20.7; 21.0; 22.1; 21.8 | 0.57 |
| SECONDARY Gait Parameters |
1.2; 1.2; 1.3; 1.2 | 0.25 |
| SECONDARY Neuropsychological Tests |
0.6; -0.7; 1.5; 0.1 | 0.75 |
| SECONDARY Quality of Life Questionnaires |
19.7; 17.8; 17.5; 11.9 | — |
| SECONDARY Movement Disorder Society - Unified Parkinsons Disease Rating Scale (MDS-UPDRS) |
51.0; 50.4; 48.2; 45.8 | — |
| SECONDARY Physical Activity Measured With Accelerometers |
4936.6; 5462.4; 4800.8; 5609.5 | — |
| SECONDARY Structural Magnetic Resonance Imaging |
0; 0 | — |
| SECONDARY Task-induced Brain Activity as Measured by Functional Magnetic Resonance Imaging |
0; 0 | — |
| SECONDARY Wet Biomarkers |
38010.8; 37805.3; 37169.4; 35945.8 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of idiopathic Parkinson´s disease
- Hoehn & Yahr 2-3
- ≥ 60 years of age
- Be able to ambulate indoors without mobility aid
- Balance impairment
Exclusion Criteria
- =< 21 points on MoCA
- Other medical conditions that could substantially influence balance performance, voice or speech performance or participation in the interventions
- Participating in an intensive exercise program for balance or speech during the last six months.
Additional exclusion criteria for the brain imaging will include the presence of; pacemakers, deep brain stimulators or other MRI incompatible implants, claustrophobia, inability to hear instructions without hearing aid, unilateral or bilateral blindness, severe diplopia, tremor, dyskinesia or dystonia.
Data sourced from ClinicalTrials.gov (NCT03213873). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.