N/A Completed N=15

Evaluation of Lipid Emulsion on GCX in Critically Ill Patients

Endothelial Dysfunction

Source: ClinicalTrials.gov NCT03216850 ↗

Enrolled (actual)

Serious AEs

—

Results posted

Nov 2019

Primary outcomePrimary: Endothelial Glycocalyx Thickness — 2.28 micrometer

Summary

Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx. The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled. Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),

Outcome Measures

Outcome	Result	p-value
PRIMARY Endothelial Glycocalyx Thickness	2.28	—

Eligibility Criteria

Inclusion Criteria

patients in ICU
indication for lipid administration as a part of TPN

Exclusion Criteria

shock or clinical/laboratory signs of tissue hypoperfusion
previous lipid infusions (within 3 months before entering study)
hyperlipidaemia
hyperglycaemia (over 10 mmol/l)
current or previous (within 72 hours before entering the study) use of propofol
pancreatitis
severe liver failure
current use of statins

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03216850). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.