N/A
N=15
Evaluation of Lipid Emulsion on GCX in Critically Ill Patients
Endothelial Dysfunction
Bottom Line
View on ClinicalTrials.gov: NCT03216850 ↗Enrolled (actual)
15
Serious AEs
—
Results posted
Nov 2019
Primary outcome: Primary: Endothelial Glycocalyx Thickness — 2.28 micrometer
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Sublingual microcirculation assessment (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University Hospital Hradec Kralove
- Primary completion
- Aug 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Endothelial Glycocalyx Thickness |
2.28 | — |
Summary
Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx.
The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled.
Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),
Eligibility Criteria
Inclusion Criteria
- patients in ICU
- indication for lipid administration as a part of TPN
Exclusion Criteria
- shock or clinical/laboratory signs of tissue hypoperfusion
- previous lipid infusions (within 3 months before entering study)
- hyperlipidaemia
- hyperglycaemia (over 10 mmol/l)
- current or previous (within 72 hours before entering the study) use of propofol
- pancreatitis
- severe liver failure
- current use of statins
Data sourced from ClinicalTrials.gov (NCT03216850). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.