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Home › Conditions › Endothelial Dysfunction

Endothelial Dysfunction

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Endothelial Dysfunction

40 trials tracked for Endothelial Dysfunction: 4 in phase 3 or 4 and 1 with published results. The most-cited published study has 11 citations.

40Trials tracked
4Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 3 1 Phase 2 14 Phase 1 5 Other / NA 17
  1. Phase 3 Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans Completed · 11 cited
  2. Phase 4 Effect of Ezetimibe on Flow-mediated Brachial Artery Reactivity in Healthy Subjects Completed
  3. Phase 4 The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation Completed
  4. Phase 4 Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes Completed
  5. Phase 2 A Phase 1/ Phase 2 Study of TTHX1114(NM141) Completed
  6. Phase 2 A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction Completed
Show 34 more trials
  1. Phase 2 CD36 in Nutrient Delivery and Its Dysfunction Completed
  2. Phase 2 Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial Completed
  3. Phase 2 Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults Completed
  4. Phase 2 A Clinical Trial for People HIV+ Age > 50 at Risk for Heart Disease Completed
  5. Phase 2 Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome Completed
  6. Phase 2 Rilonacept to Improve Artery Function in Patients With Atherosclerosis Completed
  7. Phase 2 Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function Completed
  8. Phase 2 Targeting Inflammation to Treat Cardiovascular Aging Completed
  9. Phase 2 Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women Completed
  10. Phase 2 Darusentan Effect on PET Uptake Heterogeneity Completed
  11. Phase 2 N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults Completed
  12. Phase 2 Trial of Oral Glutamine on Mitochondrial Function in CKD Completed
  13. Phase 1 Leptin Infusion and Endothelial Vasomotor Response Completed
  14. Phase 1 Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study Completed
  15. Phase 1 Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents Completed
  16. Phase 1 A Trial to Evaluate the Effect of C21 on Endothelial Dysfunction in Subjects With Type 2 Diabetes Completed
  17. Phase 1 Acute Effects of E-Cigarette Aerosol Inhalation Completed
  18. N/A Endothelial Function After Cardiac Surgery Completed
  19. N/A The Cardiovascular Effects of Electronic Hookah Vaping Completed
  20. N/A Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease Completed
  21. N/A Study of Protective Effects of Paricalcitol on Inner Layer of Vessels and Its Protective Effect on Inflammation Completed
  22. N/A FFA-Induced Hypertension and Endothelial Dysfunction Completed
  23. N/A Resveratrol and Vascular Function in CKD Completed
  24. N/A Evaluation of Lipid Emulsion on GCX in Critically Ill Patients Completed
  25. N/A Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women Completed
  26. N/A Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome Completed
  27. N/A Vitamin D Repletion in Coronary Artery Disease Completed
  28. N/A Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function Completed
  29. N/A Passive Mobilization and Vascular Function Completed
  30. N/A Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults Completed
  31. N/A Study of Niacin on Endothelial Function in HIV-infected Subjects With Low High Density Lipoprotein Cholesterol Levels Completed
  32. N/A The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women Completed
  33. N/A Effects of Body Mass Index on the Hyperemic Response to Regadenoson Completed
  34. N/A The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function Completed

Showing the 40 most-cited and recently-updated of 40 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Endothelial Dysfunction: what the trials found

Salsalate has been shown to significantly improve flow-mediated dilation (FMD) of the brachial artery over a 13-week period 17.

Ezetimibe was associated with measurable changes in flow-mediated dilation 2.

Atorvastatin showed no significant difference between groups regarding the presence of symptoms of atrial fibrillation or atrial arrhythmia at 3 months, nor did it significantly alter mean C-reactive protein levels 3.

Recent results — preliminary, needs further review

  • Nitrate-containing interventions were associated with changes in carotid artery compliance and carotid pulse pressure 1.
  • Telmisartan showed a statistically significant increase in both the diameter and flow-mediated dilation (FMD) of the brachial artery over 6 weeks 14.

For the clinician treating this condition

  • Salsalate is an established intervention for improving brachial artery flow-mediated dilation.
  • Telmisartan demonstrates statistically significant improvements in brachial artery diameter and FMD within a 6-week period.

AI synthesis of 5 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Whole-body vibration and resistance training rank highest for improving endothelial function in older adults
Cardiology Meta-analysis
Whole-body vibration and resistance training rank highest for improving endothelial function in older adults Different types of exercise impact heart health in older adults
This systematic review and network meta-analysis evaluated seven exercise modalities for cardiovascular outcomes in adults aged 60 years or …
New research shows that specific exercises like vibration training or walking can improve blood vessel health and lower blood pressure in se…
Frontiers Jul 13, 2026
Endothelial dysfunction prevalent in PCI patients; 33.7% developed contrast-associated AKI
Nephrology Cohort
Endothelial dysfunction prevalent in PCI patients; 33.7% developed contrast-associated AKI Study finds kidney injury link to blood vessel health after heart procedures
A prospective observational cohort of 187 PCI patients found 60 cases (33.7%) of contrast-associated AKI.
Poor blood vessel health is linked to kidney injury after heart procedures, a connection found in patients receiving contrast dye for corona…
Frontiers Apr 2, 2026
Resistance exercise after high-carb meal improves postprandial glucose and endothelial function in healthy adults
Physical Medicine & Rehab RCT
Resistance exercise after high-carb meal improves postprandial glucose and endothelial function in healthy adults When should you exercise after a meal to help your blood vessels?
A randomized crossover study in healthy adults found whole-body resistance exercise performed immediately after a high-carbohydrate meal imp…
Doing a full-body workout right after eating helps healthy adults lower blood sugar and improve blood vessel function better than resting or…
Apr 2, 2026