N/A
N=145
Cognitive Rehabilitation Therapy for Mild Cognitive Impairment
Mild Cognitive Impairment
Bottom Line
View on ClinicalTrials.gov: NCT03225482 ↗Enrolled (actual)
145
Serious AEs
4.1%
Results posted
Aug 2025
Primary outcome: Primary: Change in Objective Cognitive Performance Composite z Score — .24; .14 Z score
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Motivationally Enhanced Compensatory Cognitive Training (Behavioral); Goal-focused Supportive Contact (Behavioral)
- Age
- Adult, Older Adult · 55+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jun 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Objective Cognitive Performance Composite z Score |
.24; .14 | — |
| PRIMARY Change in Functional Capacity Performance Composite z Score |
.11; .17 | — |
| SECONDARY Change in Subjective Everyday Functioning Composite Score |
2.41; .64 | — |
| SECONDARY Change in Everyday Cognition Scale |
-.32; -.10 | — |
| SECONDARY Change in Cognitive Activity Inventory |
24.37; -26.80 | — |
| SECONDARY Change in CHAMPS Physical Activity Questionnaire for Older Adults |
-2.02; 1.76 | — |
| SECONDARY Change in Portland Cognitive Strategies Scale |
4.28; 1.65 | — |
| SECONDARY Change in Fitbit-measured Physical Activity Level |
146.62; -867.84 | — |
| SECONDARY Change in Fitbit-measured Sleep Time |
-25.63; 11.57 | — |
Summary
The number of older Veterans with Mild Cognitive Impairment (MCI) seeking care within the Veterans Affairs (VA) health care system is increasing and is expected to increase more rapidly as Vietnam era Veterans age. The cognitive effects of MCI and subsequent neurodegenerative disorders can adversely affect a Veteran's ability to function independently and failure to provide appropriate intervention can result in an increased need for healthcare services and VA benefits in the future. The VA currently spends over $19,000 annually per patient to care for Veterans with dementia (Zhu et al., 2009), and delaying the onset of dementia even by one to two years will result in substantial financial savings to the VA and quality of life gains for the Veteran. Since present pharmacological interventions have demonstrated limited efficacy, alternative treatments are needed. Therefore, an evidence-based cognitive training intervention that optimally addresses the needs of older Veterans with MCI is of critical importance to the VA patient care mission.
Eligibility Criteria
Inclusion Criteria
- Veterans >55 years old enrolled at one of the participating VA sites (VASDHS and VAPORHCS) who are able to provide informed consent
- Independently living
- Meet criteria for MCI based on previously published criteria (see below)
- Willingness to participate in audio-recorded sessions.
- MCI Criteria:
- Concern about a decline in cognitive functioning expressed by a physician, informant, participant or nurse
- Cognitive impairment in one or more of the following domains
- executive function
- memory
- attention
- language or visuospatial abilities
- Normal or minimal impairment in functional activities
- Does not meet criteria for dementia
Exclusion Criteria
- Current substance use disorder with 30 minutes
- Auditory or visual impairments that would prevent ability to participate in the cognitive rehabilitation group or benefit from compensatory strategies
Data sourced from ClinicalTrials.gov (NCT03225482). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.