A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity

Inclusion Criteria

• Male and female subjects aged 18 years and older.
• Willing and physically able to carry out all study procedures.
• Willing and able to give written informed consent and complete a medical history form.
• Have at least one hypersensitive tooth in two quadrants, which are anterior to the molars and demonstrate cervical dentine, which have an air-blast hypersensitivity score of 2 or 3 on the Schiff sensitivity scale at Screening and Baseline and a tactile hypersensitivity score of 10-20 grams of force at baseline.
• Willing to comply with the oral hygiene and food and drink restrictions.

Exclusion Criteria

• Subjects who have used anti sensitivity products in the 4 weeks prior to screening
• Subjects with an active oral ulcer (Aphthous ulcer), or have similar experience within past 1 month.
• Subjects who use a powered toothbrush at least 4 times a week to brush their teeth
• Subjects whose indicator teeth have abnormal oral pathology, for example:
• Extensive restorations.
• Observable caries.
• Observable cracked enamel.
• Leaking fillings or other restorations.
• Cracked Tooth Syndrome
• Suspected pulp pathology/abscess/pulpitis.
• Atypical facial pain
• Any tooth surface adjacent to those surfaces under investigation, which in the opinion of the investigator have any other condition(s) that provide confusing symptoms to those of cervical dentine hypersensitivity.
• Currently undergoing dental treatment, including orthodontic treatment.
• Subjects who have had vital bleaching within 4 weeks of the screening visit
• Known allergies to any toothpaste ingredients, including the flavour components.
• Obvious physical disability reducing tooth brushing ability.
• Receiving concomitant medication/therapy that might affect dentine hypersensitivity, e.g. regular use of analgesics, anti-histamines, non-steroidal anti-inflammatory drug and selective serotonin reuptake inhibitor medication
• Severe gingivitis, periodontitis and/or marked tooth mobility.
• Gingival surgery in the previous six months.
• In the opinion of the investigator unable to comply fully with the trial requirements.
• Participation in other dental clinical trials in the previous 28 days
• Subjects who have participated in an dentinal hypersensitivity study within the previous 1 month.
• Diabetic (both Type 1 and Type 2)
• Medical condition(s) and/or regular use of any medication, which either could affect the scientific validity of the study or if the subject was to participate in the study could, affect their wellbeing.
• Smokers or e-cigarette use or those who have smoked/vaped in the previous 12 months
• Brushing 53g of toothpaste in a two week period during the test phase
• The subject is an employee of Unilever or the site conducting the study.