N/A N=129 Randomized Single-blind Treatment

Enhancing Adolescent Substance Abuse Treatment

Substance Use Disorders

Bottom Line

View on ClinicalTrials.gov: NCT03249350 ↗

Enrolled (actual)

129

Serious AEs

10.9%

Results posted

Nov 2025

Primary outcome: Primary: Changes From Baseline Scores Compared to Post-Treatment Scores, Any Positive Youth Urine Drug/Alcohol Screens (Measured at 0, 2, 4, 6, 9, & 12 Months). — 0.68; 0.73; 0.60; 0.55 positive test per timepoint — p=0.49

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Standard Contingency Management (CM) (Behavioral); Enhanced Contingency Management (CM+) (Behavioral)
Age: Pediatric, Adult · 12+ yrs
Sex: All
Sponsor: Oregon Social Learning Center
Primary completion: Mar 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Changes From Baseline Scores Compared to Post-Treatment Scores, Any Positive Youth Urine Drug/Alcohol Screens (Measured at 0, 2, 4, 6, 9, & 12 Months).	0.68; 0.73; 0.60; 0.55; 0.51; 0.41	0.49
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Problem Behaviors (Measured at 0, 2, 4, 6, 9, & 12 Months).	22.88; 24.6; 18.07; 19.15; 17.05; 16.53	0.92
SECONDARY Youth Receipt of Required Contingency Management (CM) Treatment Components.	0.16; 0.11; 0.33; 0.37	<0.001 sig
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Parent Management - Inconsistent Discipline Subscale - Parent Report(Measured at 0, 2, 4, 6, 9, & 12 Months).	10.09; 10.62; 9.63; 9.27; 9.7; 9.11	0.09
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Parent Management - Positive Parenting Subscale - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	18.09; 17.16; 18.27; 17.06; 17.66; 17.48	0.95
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Parent Management - Poor Monitoring Subscale - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	14.35; 14.89; 14.29; 14.73; 13.59; 14.3	0.88
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Parent Management - Inconsistent Discipline Subscale (Youth Report) (Measured at 0, 2, 4, 6, 9, & 12 Months).	14.8; 14.6; 14.37; 13.63; 13.58; 13.56	0.06
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Parent Management - Positive Parenting Subscale - Youth Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	19.82; 19.57; 18.93; 19.59; 19.85; 19.41	0.50
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Parent Management - Poor Monitoring Subscale - Youth Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	25.15; 24.63; 23.04; 21.59; 21.98; 22.69	0.03 sig
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Substance Use Frequency (Measured at 0, 2, 4, 6, 9, & 12 Months).	22.89; 21.9; 13.05; 14.51; 12.18; 10.48	0.54
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Substance Problems (Measured at 0, 2, 4, 6, 9, & 12 Months).	6.73; 7.19; 3.91; 3.28; 3.33; 2.06	0.89
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - Drive - Youth Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	11.3; 11.19; 11.17; 11.02; 11.23; 11.09	0.31
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - Fun Seeking - Youth Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	11.86; 12.46; 12.04; 12.15; 12.03; 12.31	0.35
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - Reward Responsiveness - Youth Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	15.35; 15.41; 15.63; 15.26; 15.48; 15.69	0.13
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - Drive - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	11.19; 11.44; 11.92; 11.4; 11.93; 11.48	0.30
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - Fun Seeking - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	12.00; 11.84; 11.8; 11.54; 12.16; 11.86	0.70
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - Reward Responsiveness - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	15.47; 15.03; 15.29; 15.31; 15.8; 15.09	0.89
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Risk Taking - BART (Measured at 0, 2, 4, 6, 9, & 12 Months).	48.49; 51.72; 51.29; 53.86; 49.88; 53.14	0.06
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Inhibitory Control - EATQ - Youth (Measured at 0, 2, 4, 6, 9, & 12 Months).	2.96; 2.8; 3.0; 2.92; 3.01; 3.0	0.11
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Inhibitory Control - EATQ - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	2.4; 2.44; 2.47; 2.54; 2.45; 2.55	0.99
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Youth Behavioral Regulation - Inhibitory Control - Go No Go Performance (Measured at 0, 2, 4, 6, 9, & 12 Months).	0.74; 0.74; 0.75; 0.71; 0.73; 0.73	0.82
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Peer Relations - Peer Delinquency (Measured at 0, 2, 4, 6, 9, & 12 Months).	15.42; 14.83; 9.89; 10.06; 9.38; 11.41	0.23
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Peer Relations - Positive Peer Activity - Youth Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	16.62; 15.16; 17.37; 16.0; 17.2; 16.28	0.73
SECONDARY Changes From Baseline Scores Compared to Post-Treatment Scores for Peer Relations - Positive Peer Activity - Parent Report (Measured at 0, 2, 4, 6, 9, & 12 Months).	9.8; 10.51; 10.41; 11.4; 11.14; 11.0	0.31

Summary

The ultimate goal of this research is to facilitate rapid enhancement of youth substance abuse treatments by determining the key mechanisms of change (i.e., what to target more intensely to generate better outcomes). This work is critical because current outpatient adolescent substance abuse treatments yield only small to medium effects that diminish once treatment has ended. The proposed modern mediation study will address this serious public health problem by experimentally evaluating the most critical factors causing change in client outcomes during adolescent substance abuse treatment, directing the field to focus treatment efforts on those factors.

Eligibility Criteria

Inclusion Criteria

Age 12 to 18 years
Presence of current substance use disorder
Availability of a parent/guardian willing to participate

Exclusion Criteria

Actively psychotic, suicidal, or homicidal
Pervasive developmental disorder or metal retardation

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03249350). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.