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Home › Conditions › Substance Use Disorder

Substance Use Disorder

Part of Substance-Related Disorders

19 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Substance Use Disorder

117 trials tracked for Substance Use Disorder: 12 in phase 3 or 4 and 6 with published results. The most-cited published study has 312 citations.

117Trials tracked
12Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 6 Phase 3 6 Phase 2 13 Phase 1 5 Other / NA 87
  1. Phase 4 Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of Care Completed · 312 cited
  2. Phase 4 Feasibility and Acceptability of Digital Pills to Monitor PrEP Adherence in MSM With Substance Use Completed · 35 cited
  3. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 27 cited
  4. Phase 3 Homeless Care Management App Completed · 18 cited
  5. Phase 4 Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder Completed
  6. Phase 3 Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users (PrEPSteps) Completed
Show 44 more trials
  1. Phase 4 Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation Completed
  2. Phase 4 PrEP at a Syringe Services Program Completed
  3. Phase 4 Creatine as a Treatment Option for Depression in Methamphetamine Using Females Completed
  4. Phase 3 Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders Completed
  5. Phase 3 Adaptive Treatment for Alcohol and Cocaine Dependence Completed
  6. Phase 3 Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD) Completed
  7. Phase 2 Cognitive Stimulation Completed
  8. Phase 2 Guanfacine to Improve Substance Use Outcomes in Women Completed
  9. Phase 2 Pharmacogenetics of Naltrexone for Stimulant Abuse Completed
  10. Phase 2 Varenicline Treatment for Cannabis Use Disorder Completed
  11. Phase 2 The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use Completed
  12. Phase 2 Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment Completed
  13. Phase 2 Gabapentin for Bipolar & Cannabis Use Disorders Completed
  14. Phase 2 SMART Trial: Intrapersonal and Interpersonal Stigma Reduction Completed
  15. Phase 2 The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention Completed
  16. Phase 2 Brief Intervention in At-Risk First-time Mothers Completed
  17. Phase 2 Benzodiazepine Discontinuation in Opioid Agonist Therapy Completed
  18. Phase 2 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress Completed
  19. Phase 2 Mindfulness Based Relapse Prevention: Efficacy and Mechanisms Completed
  20. Phase 1 Multiple Ascending Dose Study of TMP-301 in Healthy Subjects Completed
  21. Phase 1 A Social Network AOD Intervention for Homeless Youth Transitioning to Housing Completed
  22. Phase 1 Woebot for Substance Use Disorders Completed
  23. Phase 1 W-SUDs for COVID-19 Completed
  24. Phase 1 A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants Completed
  25. N/A Southwest Hub for American Indian Youth Suicide Prevention Research Completed
  26. N/A Providing Expanded Continuous Labor Support to Pregnant Women in New Mexico With Substance Use Disorders Completed
  27. N/A The Substance Use and Health Risk Intervention (SUHRI) for Justice-involved Youth Completed
  28. N/A Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use Completed
  29. N/A Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care Completed
  30. N/A Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT Completed
  31. N/A Assessing the Effect of Distance Learning Vocational Rehabilitation on Employment Outcomes of Veterans With Psychiatric Illness and Histories of Legal Convictions Completed
  32. N/A Home Visitation Enhancing Linkages Project Completed
  33. N/A Using Aromatherapy in Substance Use Disorder Completed
  34. N/A Justice-Involved Veterans and Moral Reconation Therapy Completed
  35. N/A Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE) Completed
  36. N/A Collaborating to Implement Cross-System Interventions in Child Welfare and Substance Use Completed
  37. N/A Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs Completed
  38. N/A Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment Completed
  39. N/A Connect2BWell: An Evidence-Based Screening, Brief Intervention, and Referral to Treatment (SBIRT) Program Completed
  40. N/A Pilot of Pragmatic SBIRT Study Completed
  41. N/A Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study Completed
  42. N/A Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase Completed
  43. N/A Advancing Understanding of Transportation Options Completed
  44. N/A SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study) Completed

Showing the 50 most-cited and recently-updated of 117 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Social exclusion and cultural barriers hinder substance use service access for immigrants in Europe
Primary Care & Family Medicine Sys. Review
Social exclusion and cultural barriers hinder substance use service access for immigrants in Europe Social exclusion blocks immigrants from addiction care in Europe
This systematic scoping review identifies significant barriers to substance use services for immigrants in Europe, including language challe…
Language, stigma, and discrimination keep immigrants in Europe from getting help for substance use, a new review finds.
Frontiers Jun 10, 2026
Plant-derived compounds show potential for substance use disorders, depression, anxiety
Drug Pipeline Sys. Review
Plant-derived compounds show potential for substance use disorders, depression, anxiety Plant extracts may help with depression and anxiety, but more research is needed
This narrative review examines plant-derived metabolites and essential oils from Hypericum perforatum, Rhodiola rosea, and Withania somnifer…
A review suggests plant-derived compounds like St. John's Wort and Rhodiola might help with mood disorders, though effects need further vali…
Frontiers Jun 2, 2026
Modified strategies for integrating mental health into NCD care in India
Primary Care & Family Medicine Guideline
Modified strategies for integrating mental health into NCD care in India India’s Mental Health Care Gets a New Blueprint for Action
Nine implementation strategies were modified to integrate mental and substance use disorder screening into NCD care in India, showing feasib…
India is testing a smarter way to treat mental health conditions inside regular diabetes and heart disease clinics, and early results show i…
Frontiers May 13, 2026
Mini review notes elevated substance use in sexual minority women compared to heterosexual women
Psychiatry Sys. Review
Mini review notes elevated substance use in sexual minority women compared to heterosexual women Substance use is higher among sexual minority women than heterosexual women
This narrative mini review examines substance use patterns in sexual minority women (SMW) versus heterosexual women. The authors synthesize …
A review shows substance use is more common among sexual minority women. Bisexual women face the highest risk. This review highlights the ne…
Frontiers May 7, 2026
Scoping review of mental health in sub-Saharan African university students during COVID-19
Primary Care & Family Medicine Sys. Review
Scoping review of mental health in sub-Saharan African university students during COVID-19 Mental health crisis among African university students revealed
This systematic scoping review synthesized evidence on mental health among university students in sub-Saharan Africa during the COVID-19 pan…
Depression, anxiety, and suicidality are common among university students in sub-Saharan Africa, but help-seeking is rare. A new review maps…
Frontiers Apr 23, 2026
Systematic review of mobile health just-in-time adaptive interventions for youth mental health and substance use
Pediatrics Meta-analysis
Systematic review of mobile health just-in-time adaptive interventions for youth mental health and substance use Smartphone Alerts That Learn Your Teen’s Habits May Boost Mental Health
This systematic review synthesized 61 mobile health just-in-time adaptive interventions for adolescents and young adults.
This could change how mental health care works for young people — before crises happen.
medRxiv Apr 23, 2026
HIV outbreak reported among persons who inject drugs in Kanawha County, West Virginia
Infectious Disease
HIV outbreak reported among persons who inject drugs in Kanawha County, West Virginia HIV outbreak reported among people who inject drugs in West Virginia county
A descriptive outbreak investigation report documented an HIV outbreak among persons who inject drugs in Kanawha County, West Virginia, duri…
Health officials report an HIV outbreak among people who inject drugs in Kanawha County, West Virginia, during the pandemic.
CDC Apr 6, 2026
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries
Infectious Disease
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries Analysis looks at overdose deaths involving both opioids and stimulants across different jobs
An observational report analyzed synthetic opioid and stimulant co-involved overdose deaths across occupations and industries in the United …
A new analysis examines how different jobs and industries might connect to overdose deaths involving both synthetic opioids and stimulants.
CDC Apr 5, 2026
Survey examines substance use patterns among U.S. high school students before and during COVID-19
Infectious Disease
Survey examines substance use patterns among U.S. high school students before and during COVID-19 Survey examines substance use patterns among U.S. high school students during the pandemic
An observational survey report examined substance use patterns among U.S.
A survey looked at how substance use patterns among U.S. high school students may have changed during the COVID-19 pandemic compared to befo…
CDC Apr 5, 2026
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses
Infectious Disease
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses What prescriptions did people have before dying from an overdose in Pennsylvania?
An observational report from Pennsylvania analyzed controlled substance prescribing patterns preceding fatal overdoses involving opioids, st…
A new Pennsylvania report maps the controlled substance prescriptions people received before dying from an overdose involving opioids or sti…
CDC Apr 5, 2026
Report describes alcohol and substance co-use among pregnant females in the United States
OB/GYN & Women's Health
Report describes alcohol and substance co-use among pregnant females in the United States Report examines alcohol and substance use patterns among pregnant people in the US
An observational report describes alcohol and substance co-use among pregnant females aged 12-44 years in the United States.
A new report looks at how often pregnant people in the US use alcohol and other substances together, aiming to clarify current trends.
CDC Apr 4, 2026
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use
Psychiatry Phase III
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use Hong Kong trial planned to test antipsychotic injections for substance use with psychosis
A trial record describes a planned phase 2/3 study of 165 individuals in Hong Kong with substance use disorders and psychosis.
Hong Kong researchers plan a trial to test long-acting antipsychotic injections for people with substance use disorders and psychosis.
CT.gov Apr 3, 2026

Research across Substance-Related Disorders

Related studies from across the Substance-Related Disorders family.

Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study
Diabetes & Endocrinology Cohort
Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study Semaglutide linked to lower neuropsychiatric risk than other diabetes drugs
This observational cohort study analyzed 63,215 patients with baseline neuropsychiatric conditions across a large US federated data platform…
A large observational study suggests semaglutide may be associated with a lower risk of neuropsychiatric conditions compared to other common…
medRxiv Apr 24, 2026
Cannabis-involved ED visits increased among US youth during COVID-19 pandemic
Infectious Disease
Cannabis-involved ED visits increased among US youth during COVID-19 pandemic Cannabis-related emergency visits rose among young people during COVID-19 pandemic
A US report found cannabis-involved emergency department visits were higher among persons under 25 during the COVID-19 pandemic period compa…
Emergency visits for cannabis use among young people rose during the COVID-19 pandemic compared to before.
CDC Apr 5, 2026
Field report describes overdose deaths involving eutylone, a psychoactive bath salt, in the United States
Psychiatry
Field report describes overdose deaths involving eutylone, a psychoactive bath salt, in the United States What happens when people overdose on the bath salt drug eutylone?
A field report describes overdose deaths involving eutylone, a psychoactive bath salt, in the United States.
A new report confirms that eutylone, a dangerous synthetic stimulant often sold as bath salts, is causing fatal overdoses in the United Stat…
CDC Apr 3, 2026

Questions about Substance Use Disorder

How do just-in-time adaptive interventions help adolescents with substance use problems?

Just-in-time adaptive interventions (JITAIs) help adolescents by delivering personalized support at the exact moment they face risk, using real-time data to improve engagement and reduce substance use.

Full answer →
What mobile health apps help youth with mental health and substance use?

Mobile apps like Mind your Mate help youth reduce depression and alcohol use by offering peer support and real-time tools, though effectiveness varies by app type and user needs.

Full answer →
Do sexual minority women have higher substance use rates than heterosexual women?

Research shows sexual minority women have higher rates of substance use and related disorders than heterosexual women, with bisexual women often facing the highest risk.

Full answer →
How did Substance Use Disorders change among US high school students before and during the pandemic?

Substance use among US high school students decreased overall during the pandemic, but disparities widened for certain groups, including sexual minority youth and those experiencing racial/ethnic stress.

Full answer →
Do sexual minority women have higher rates of Substance Use Disorders compared to heterosexual women?

Research confirms that sexual minority women have higher rates of substance use disorders than heterosexual women, with bisexual women often facing the highest risk.

Full answer →
See all 5 questions about Substance Use Disorder →

All Substance Use Disorder Articles