N/A
N=70
Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
Oxidative Stress · Inflammation · Blood Pressure · Vasoconstriction · Coagulation
Bottom Line
View on ClinicalTrials.gov: NCT03255187 ↗Enrolled (actual)
70
Serious AEs
0.0%
Results posted
Jan 2020
Primary outcome: Primary: Biomarkers of Antioxidant Activity-Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) — 6.09; 5.80; 364.34; 356.59 U/ml
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Fish oil supplementation (Dietary_supplement); Sunflower seed oil supplementation (Dietary_supplement)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Fudan University
- Primary completion
- Jan 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Biomarkers of Antioxidant Activity-Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) |
6.09; 5.80; 364.34; 356.59 | — |
| PRIMARY Biomarkers of Inflammation-Interleukin-6 (IL-6) and Tumour Necrosis Factor-α (TNF-α) |
0.72; 1.76; 0.35; 0.54 | — |
| PRIMARY Cogulation Biomarker-von Willebrand Factor (vWF) |
1669.70; 2144.30 | — |
| PRIMARY Biomarkers of Endothelial Function and Stress Hormone |
12.23; 14.16; 5.99; 4.29; 2.96; 3.06 | — |
| PRIMARY Endothelial Function Biomarker-Endothelin-1(ET-1) |
1.80; 2.82 | — |
| PRIMARY Cogulation Biomarker-Fibrinogen |
2.25; 2.63 | — |
| PRIMARY High-sensitivity C-reactive Protein (Hs-CRP)-an Inflammatory Biomarker |
12.81; 19.93 | — |
| PRIMARY Oxidized Low Density Lipoprotein (Ox-LDL)-an Oxidative Stress Biomarker |
34.74; 40.11 | — |
| PRIMARY Glutathione Peroxidase (GSH-Px)-a Biomarker of Antioxidant Activity |
625.95; 581.51 | — |
| PRIMARY Serum Level of Lipid Peroxidation (LPO)-a Biomarker of Oxdative Stress |
0.54; 0.58 | — |
| SECONDARY Blood Pressure |
110.01; 111.55; 67.20; 67.29 | — |
| SECONDARY Insulin Resistance |
1.40; 1.42 | — |
| SECONDARY Skin Inflammation Biomarkers |
184.49; 230.90; 54.00; 42.00 | — |
| SECONDARY Skin Oxidative Stress Biomarker-Carbonyl Protein |
35.93; 44.89 | — |
| SECONDARY Lung Function-Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 Second (FEV1) |
3.18; 3.16; 3.75; 3.73 | — |
| SECONDARY Lung Function-Peak Expiratory Flow (PEF) |
6.55; 6.38 | — |
| SECONDARY Skin Antioxidant Biomarker-Total Antioxidant Capacity (TAC) |
42.99; 35.73 | — |
| SECONDARY Skin Antioxidant Biomarker-Glutataione (GSH) |
2.21; 0.42 | — |
Summary
This study aims to evaluate whether dietary supplementation with fish oil can protect against the cardiopulmonary alterations linked to air pollution
Eligibility Criteria
Inclusion Criteria
- Equal to or older than 18 years old.
- No history of smoking and alcohol addiction.
- No chronic diseases or respiratory or allergic diseases,such as hypertension,diabetes,chronic obstructive pulmonary disease,other respiratory/cardiovascular diseases, asthma, rhinitis or other allergic diseases reported by volunteers.
- No allergies to n-3 PUFA or fish.
Exclusion Criteria
- Current smokers or ever smokers
- Chronic drug use due on cardiovascular or respiratory diseases
- Participants are taking fish oil, anti-inflammatory drugs, or antioxidant supplements (such as vitamin C or vitamin E)
Data sourced from ClinicalTrials.gov (NCT03255187). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.