N/A N=42 Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes
Type 2 Diabetes · Oxidative Stress
Primary: Concentration of Vitamin C in Type 2 Diabetic Patients. — 1.1; 1.2 umol/g tissue
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=102 Pilot Study Assessing Oxidative Stress in Children
Adrenal Insufficiency · Critical Illness
Primary: Pediatric Logistic Organ Dysfunction Score in Critically Ill Children — 15.9 scores on a scale
Phase 2 N=49 Oxidative Stress in Asthma
Asthma · Obesity
Primary: Percentage of Neutrophils in Peripheral Blood — 57.3; 55.4 percentage of neutrophils — p=0.53
N/A N=28 Exercise, Oxidative Stress and HIV
HIV Infections
Primary: Total Glutathione — 1,964; 3,490; 1,865; 3,995 nmoles glutathione/ ml of sample — p=<0.05
Phase 2 N=24 Oxidative Stress and Surgical Recovery
Surgical Recovery · Pain, Postoperative
Primary: Phosphorylation of STAT-3 in MDSC (Myeloid-derived Suppressor Cells) — 2.162; 2.025 STAT3 archsinh ratio — p=0.5490
Phase 2 N=36 Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells
Diabetes Mellitus · Metabolic Syndrome X · Hypercholesterolemia
Primary: Change in Plasma Thiobarbituric Acid Reactive Substance (TBARS) Levels — 2.1; 2.5 nmol/mL
N/A N=43 Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
Asthma · Pulmonary Disease, Chronic Obstructive
Primary: 8-isoprostane Levels as Biochemical Markers for Nonenzymatic Oxidative Stress in Asthma — 292.4; 421.8 pg/ml
Phase 2 N=325 Provision of Antioxidant Therapy in Hemodialysis (PATH) Study
End-stage Renal Disease
Primary: F2-isoprostane (F2-iso) — 0.077; 0.073 ng/ml — p=>0.05
Phase 3 N=70 Effect of Omega 3 Fatty Acids on Oxidative Stress in HIV Seropositive Patients
HIV/AIDS
Primary: Change on Malondialdehyde After Treatment With Omega 3 Acids for 6 Months Compared With Placebo in HIV Seropositive Patients — -1.18; -0.9 nM/mg protein
N/A N=25 The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea
Sleep Apnea
Primary: Flow Mediated Dilation — 5.7; 9.5; 7.3 percentage change of vessel diamter — p=0.02
Phase 2 N=64 Cystic Fibrosis and Endothelial Function: At Rest and During Exercise
Cystic Fibrosis
Primary: Percentage Flow-Mediated Dilation (FMD) — 5.64; 5.32; 6.29; 7.21 percentage of change in FMD
N/A N=57 Oxidized Omega-3 Supplements With Different Oxidation
Overweight
Primary: Weight (Kilogram) of Volunteers at the Beginning (Day 1) and at the End of the Study (Day 30) — 70.17; 68.77; 75.15; 69.38 kilogram
N/A N=153 Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep Apnea Syndromes · Oxidative Stress · Cardiovascular Diseases
Primary: F2-isoprostanes/Cr — -0.02; -0.08 ng/mg — p=0.38
N/A N=10 Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study A
Diabetes Mellitus, Type 1
Primary: Glutathione Concentration — 541; 551 umol/L
N/A N=14 Examining Endogenous Antioxidant Levels in Well Trained Cyclists
Oxidative Stress
Primary: Difference in Resting Levels of Endogenous Antioxidant Proteins in Skeletal Muscle - Superoxide Dismutase 2 (SOD-2) — 0.42; 0.68 Arbitrary Units
N/A N=33 Study on the Role of Treatment With Vitamin E on Asthmatic Responses in Allergic Asthmatics
Allergic Asthma
Primary: Effect of Natural-source d-α-tocopheryl Acetate on the Baseline and Allergen-induced Levels of F2-isoprostanes in the Bronchoalveolar Lavage Fluid (BAL)
N/A N=40 Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
Diabetes Mellitus, Type 1
Primary: Glutathione Concentration — 706; 734 umol/L
N/A N=53 The Effect of Methylphenidate Treatment on Oxidative Stress Levels in Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder (ADHD)
Primary: Change in Total Oxidant Status — 6.29; 5.62 U/ml — p=<0.001
Phase 3 N=80 Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress
Hyperlipidemia · Blood Pressure · Oxidative Stress
Primary: LDL — 19.67; 20.04; 5.33; 0 mg/dL
N/A N=225 Redox Determinants of Severe Asthma (a Substudy of the Severe Asthma Research Program)
Asthma
Primary: Exhaled Nitric Oxide at Baseline and Over the Observational Period — 15.1; 9.9; 13.7; 8.6 parts per billion
N/A N=75 Understanding the Exercise-Hypertension Paradox
Hypertension
Primary: Blood Pressure — 103; 106; 94; 101 mmHg
N/A N=22 The Effect of Januvia (Sitagliptin) on Oxidative Stress in Obese Type 2 Diabetic Subjects
Type 2 Diabetes
Primary: Change in Reactive Oxygen Species (ROS) Generation by MNC, Protein and mRNA Expression of p47phox Subunit of NADPH Oxidase, in MNC's of Obese Type 2 Diabetic Patients…
N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
N/A N=31 Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status
Obesity · Metabolic Syndrome · Hyperuricemia
Primary: Percent Increase in Insulin-stimulated Glucose Uptake — 231; 162; NA; 156 % incr. in insulin-mediated gluc. uptake
Phase 2 N=27 The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Myocardial Ischemia
Primary: Heme Oxygenase-1 (HO-1) Messenger Ribonucleic Acid (mRNA) Levels (Atrial Tissue) — 392.7; 229.8; 10.8 arbitrary units — p==0.001
Phase 2 N=73 Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis
Cystic Fibrosis
Primary: Change in Sputum Myeloperoxidase (MPO) Level — -0.10; 0.03 log10 (ng/mL) — p=0.460
N/A N=60 Fundus Findings and Thiol-Disulfide Homeostais
Gestational Diabetes · Eye Diseases · Retinal Disease
Primary: Glucose Levels of the Groups in Pregnant Women With Impaired Blood Sugar and/or Gestational DM — 111.67; 154; 83.06; 88.15 mg/dl
N/A N=110 Mitochondrial Stress, Brain Imaging, and Epigenetics
Mitochondrial Diseases
Primary: Average TSST-induced Elevation in Cortisol — 37.44; 33.86; 42.83; 45.42 ng*min/mL
N/A N=18 Airway Smooth Muscle and Asthma Severity
Asthma
Primary: Difference in ASM Mass Between Groups
Phase 2 N=24 N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults
HIV · Endothelial Dysfunction · Oxidative Stress
Primary: Change in Circulating Malondialdehyde Levels — 0.17; -0.12; -0.00 micromolar